Targeting Functional Centers of the Ribosome / Springer Theses (PDF)
- Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.
- Autor: Chen Davidovich
- 2011, 2011, 74 Seiten, Englisch
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3642169317
- ISBN-13: 9783642169311
- Erscheinungsdatum: 02.02.2011
Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: PDF
- Grösse: 2.56 MB
- Ohne Kopierschutz
- Vorlesefunktion
| Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
|---|
Schreiben Sie einen Kommentar zu "Targeting Functional Centers of the Ribosome / Springer Theses".
Kommentar verfassen