Targeting Functional Centers of the Ribosome
(Sprache: Englisch)
Targeting Functional Centers of the Ribosome investigates the mode of function, inhibition, and evolution of the Peptidyl Transferase Center (PTC) by a combination of X-ray crystallography, biochemistry, molecular biology and theoretical studies.
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Targeting Functional Centers of the Ribosome investigates the mode of function, inhibition, and evolution of the Peptidyl Transferase Center (PTC) by a combination of X-ray crystallography, biochemistry, molecular biology and theoretical studies.
Klappentext zu „Targeting Functional Centers of the Ribosome “
This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.Inhaltsverzeichnis zu „Targeting Functional Centers of the Ribosome “
Introduction.- Methods.- Results.- Discussion.
Bibliographische Angaben
- Autor: Chen Davidovich
- 2011, 2011, XIV, 74 Seiten, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3642169309
- ISBN-13: 9783642169304
- Erscheinungsdatum: 03.02.2011
Sprache:
Englisch
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