Metabolism and Epigenetic Regulation: Implications in Cancer / Subcellular Biochemistry Bd.100 (PDF)
- Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed.
The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAsas well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer.
Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer.
Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.
Dr. Chandrima Das is Associate Professor in Biophysics and Structural Genomics Division, Saha Institute of Nuclear Physics (SINP) Kolkata. Dr. Das obtained her Ph.D. from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India in 2007 with specialization in chromatin structural regulation by Nonhistone Chromatin Associated Protein (NCAP). She performed her post-doctoral research at University of Colorado Denver (2008-2010) and M D Anderson Cancer Center (2010-2012) on discovery and functional characterization of a novel human epigenetic mark, H3K56Ac. She was awarded Susan G. Komen Postdoctoral Fellowship for basic sciences in Breast Cancer Research (2009). In summer 2012, Dr. Das joined as a faculty in Saha Institute of Nuclear Physics (SINP) and established the Chromatin Dynamics Laboratory. Her focus has been onthe modulation of chromatin structure by selective epigenetic recognition by a class of proteins entitled chromatin "reader/effector". She is trying to understand the diverse functions of this chromatin-binding transcription factors to dictate the on/off state of the underlying genes in different physiological conditions and pathological states like cancer, metabolic as well as infectious diseases. She has been awarded Ramalingaswami fellowship from Department of Biotechnology (2011-12), SwarnaJayanti Fellowship from Department of Science and Technology (2017-18) and S. Ramachandran - National Bioscience Award for Career Development - 2019, from Department of Biotechnology. She is an elected member of West Bengal Academy of Science and Technology (WAST), a Society that promotes basic and applied science and technology in the state of West Bengal, India. She is the Life Member of Indian Society of Cell Biology (ISCB), Indian Association for Cancer Research (IACR), Society of Biological Chemists (SBC), India, Chemical Biology Society (CBS), India and a Member of The American Society for Biochemistry and Molecular Biology (ASBMB). Recently, she has been nominated as a member of The ACS Chemical Biology Early Career Board.
- 2022, 1st ed. 2022, 620 Seiten, Englisch
- Herausgegeben: Tapas Kumar Kundu, Chandrima Das
- Verlag: Springer International Publishing
- ISBN-10: 3031076346
- ISBN-13: 9783031076343
- Erscheinungsdatum: 27.10.2022
Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: PDF
- Grösse: 16 MB
- Ohne Kopierschutz
- Vorlesefunktion
Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
---|
Schreiben Sie einen Kommentar zu "Metabolism and Epigenetic Regulation: Implications in Cancer / Subcellular Biochemistry Bd.100".
Kommentar verfassen