Stress, Trauma and Synaptic Plasticity (PDF)
This book provides detailed insights into the cellular and molecular alterations that occur in the brain following stress and trauma.
The changes to the grey matter in certain areas of the brain are similar in stressed...
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This book provides detailed insights into the cellular and molecular alterations that occur in the brain following stress and trauma.
The changes to the grey matter in certain areas of the brain are similar in stressed humans and animals, with the most likely basis for these changes being the degeneration of synaptic connections. In the book's initial sections, the reader will learn about the core network of synaptic connections that are affected by stress and trauma disorders. These connections are chiefly modulated by dopamine, serotonin and Brain Derived Neurotrophic Factor (BDNF). In subsequent chapters, the NMDA-receptor-mediated plasticity of these synapses is discussed, with particular attention paid to how glucocorticoids can interfere with the function of BDNF and thereby affect the synapse's physical stability. The book concludes by integrating the observations made in the previous sections so as to present plausible hypotheses regarding the identity of the networks, synapses and molecular pathways that promote fear and extinction.
Providing an up-to-date overview of the mechanisms of synaptic plasticity and physiological changes in the stressed and traumatized brain, this book will appeal to researchers, clinicians and students in the neurosciences.
Professor J. Lagopoulos is the inaugural director of the Sunshine Coast Mind and Neuroscience - Thompson Institute, which focuses on mental health and neurological research, clinical services and teaching. He is an expert in magnetic resonance imaging (MRI) and has been involved in neuroimaging for over 20 years. His work focuses on youth mental health, post-traumatic stress disorders and traumatic brain injury. Prof. Lagopoulos is a leading academic and imaging specialist who has published more than 180 peer-reviewed papers and contributed to several books. He is member of numerous international societies, including the 'International Society for Magnetic Resonance in Medicine' and the 'Organization of Human Brain Mapping'. He has received numerous awards, including a NARSAD independent investigator award.
- Autoren: Maxwell Bennett , Jim Lagopoulos
- 2019, 1st ed. 2018, 231 Seiten, Englisch
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319911163
- ISBN-13: 9783319911168
- Erscheinungsdatum: 01.02.2019
Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: PDF
- Grösse: 5.60 MB
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