Receptors and lon Channels (PDF)

Frontmatter -- PREFACE -- CONTENTS -- I. RECEPTORS -- A) NICOTINIC ACETYLCHOLINE RECEPTOR -- The Ion Channel of the Nicotinic Acetylcholine Receptor -- Pattern Recognition in Structural Analysis of the Acetylcholine Receptor -- Selective Labeling Study on Topography of Acetylcholine Receptor and Bacteriorhodopsin -- Monoclonal Antibodies as Functional Probes of the Nicotinic Acetylcholine Receptor -- Binding of 3H-Acetylcholine to Membrane-Bound Acetylcholine Receptor -- The Nicotinic Acetylcholine Receptor is an Allosteric Protein; The Specific Allosteric Model does not apply to the Receptor's Molecular Mechanism of Action -- Organization and Function of the Cholinergic Synapse -- Directed Modification of the Brain Cholinergic System -- Molecular Mechanisms of Channel Blockade in Neuronal Nicotinic Acetylcholine Receptor -- Properties of the High Affinity Choline Carrier and Acetylcholine Receptors in the Nervous System of Insects -- B) OTHER RECEPTORS -- Effect of Sulfhydryl Reagents on Antagonist Binding with Muscarinic Receptors -- Biochemistry and Molecular Biology of Receptors and Ion Channels in the Central Nervous System (CNS) -- Reconstitution of Glutamate Receptors into Planar Bilayers -- Pharmacological Properties of Amino in Isolated Hippocampal Neurons -- II. ION CHANNELS -- cAMP-activated Ionic Channels in the Nerve Cell Membrane -- External Ca Ions Block Na Conducting Ca Channel by Promoting Open to Closed Transitions -- Effects of Changing External Calcium Concentration on Calcium Current in Isolated Smooth Muscle Cell -- Activation by Histamine Ionic Channels in the Membrane of Human Endothelial Cells -- Block of Sodium Channels with Chemically Modified Gating -- Potassium Currents in the Isolated Single Smooth Muscle Cell Membrane -- Purification and Properties of the TTX-Sensitive Protein from Bovine Brain Soluble Fraction -- Properties of Receptor-Operated Calcium Channels in Platelets -- III. SECOND MESSENGER SYSTEMS -- Isolation, Physico-Chemical Properties and Reconstitution of the Components of Adenylate Cyclase System -- Structure of Catalytic Component of Adenylate Cyclase System Revealed by Electron Microscopy -- Protein Kinases and the Dopaminergic System -- Interactions Between Proteins Involved in the Activation and Subsequent Deactivation of Phosphodiesterase in Visual Rod Cells -- Phosphorylation of the Nicotinic Acetylcholine Receptor by cAMP-dependent Protein Kinase -- IV. PUMPS -- Photoelectrical Activity of Bacteriorhodopsin in Planar Lipid Bilayer -- Position and Orientation of the Retinal Chromophore in the Two-dimensional Projected Density of the Purple Membrane -- The Light-energized H+-Pump Bacteriorhodopsin: A Model System for Functional Transmembrane Reconstitution of Ion Channels, Receptors, and Pumps -- Use of Monoclonal Antibodies to Study Bovine Rhodopsin -- Na+, K+-Pump: Structural Organisation -- ATP-Dependent Electric Currents Na+K+ Pump -- V. NEUROTOXINS -- Argiopin - A Naturally-Occurring Blocker of Glutamate- Sensitive Synaptic Channels -- Isolation of Isotoxins from the Sea Anemone Anemonia sulcata by HPLC-Chromatography -- Reconstruction of Solution Spatial Structure of Neurotoxin M9 Buthus Eupeus by Distance Geometry Algorithm According to NMR Spectroscopy Data -- Structural and Functional Comparison of Snake Neurotoxins and Curare-like Acetylcholine Antagonists. The "Active Triangle" Hypothesis -- AUTHOR INDEX -- SUBJECT INDEX -- Backmatter