Protein Allostery in Drug Discovery / Advances in Experimental Medicine and Biology Bd.1163 (PDF)
(Sprache: Englisch)
The book focuses on protein allostery in drug discovery. Allosteric regulation, 'the second secret of life', fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to...
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Produktinformationen zu „Protein Allostery in Drug Discovery / Advances in Experimental Medicine and Biology Bd.1163 (PDF)“
The book focuses on protein allostery in drug discovery. Allosteric regulation, 'the second secret of life', fine-tunes virtually most biological processes and controls physiological activities. Allostery can both cause human diseases and contribute to development of new therapeutics. Allosteric drugs exhibit unparalleled advantages compared to conventional orthosteric drugs, rendering the development of allosteric modulators as an appealing strategy to improve selectivity and pharmacodynamic properties in drug leads. The Series delineates the immense significance of protein allostery-as demonstrated by recent advances in the repertoires of the concept, its mechanistic mechanisms, and networks, characteristics of allosteric proteins, modulators, and sites, development of computational and experimental methods to predict allosteric sites, small-molecule allosteric modulators of protein kinases and G-protein coupled receptors, engineering allostery, and the underlying role of allostery in precise medicine. Comprehensive understanding of protein allostery is expected to guide the rational design of allosteric drugs for the treatment of human diseases. The book would be useful for scientists and students in the field of protein science and Pharmacology etc.
Autoren-Porträt
Dr. Jian Zhang is Professor at Shanghai Jiao Tong University School of Medicine, Shanghai, China; Dr. Ruth Nussinov is Professor in the Section of Computational Structural Biology, Cancer and Inflammation Program, National Cancer Institute, USA
Bibliographische Angaben
- 2019, 1st ed. 2019, 384 Seiten, Englisch
- Herausgegeben: Jian Zhang, Ruth Nussinov
- Verlag: Springer-Verlag GmbH
- ISBN-10: 9811387192
- ISBN-13: 9789811387197
- Erscheinungsdatum: 09.11.2019
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- Dateiformat: PDF
- Grösse: 10 MB
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Sprache:
Englisch
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