Molecular and Cellular MR Imaging (PDF)
(Sprache: Englisch)
The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical...
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The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and cellular biology, chemistry, physics, image analysis, and drug discovery to develop and translate promising approaches into reliable scientific applications and viable clinical diagnostic tools.Bringing together a select panel of internationally recognized authors, Molecular and Cellular MR Imaging provides a state-of-the-science overview of the multidisciplinary nature of the field and illustrates the application of these various sciences to investigate specific biological processes in animals and humans. Using a systematic organization to present diverse information, the text begins with an introductory chapter that defines cellular and molecular imaging and explains why magnetic resonance imaging (MRI) is the most versatile approach for noninvasive, in vivo studies. The first section examines the physicochemical principles of various contrast agents including paramagnetic, superparamagnetic, CEST, and PARACEST agents, as well as smart and sensing agents. The second section summarizes the wide variety of applications for molecular imaging of genes and of disease states. Contributions cover cancer, apoptosis, cardiovascular and neurodegenerative disease, and the use of pharmacological MRI. The third section is devoted to cellular imaging under a variety of applications, and the final section discusses the translational aspects and future directions of cellular and molecular MR imaging. Molecular and Cellular MR Imaging highlights the diversity of skills required to translate advancements in various fields of research into practical applications that promise to revolutionize in vivo imaging as a diagnostic tool.
Autoren-Porträt
Michel M.J. Modo, Ph.D. , a Luxembourg native, is a Research Council of the United Kingdom (RCUK) fellow and Wolfson lecturer in stem cell imaging at the Centre for the Cellular Basis of Behaviour and the Medical Research Council (MRC) Centre for Neurodegeneration Research at the Institute of Psychiatry (IoP), King's College London. Dr. Modo graduated from Royal Holloway University of London with a degree in psychology and in 1995 spent 1 year as an undergraduate in the psychology department at McGill University in Montreal, Canada. In 2001, he earned his Ph.D. at the IoP and has since been interested in the application of molecular and cellular imaging to understand how stem cells promote functional recovery after brain damage., Jeff W.M. Bulte, M.D., also a native from the Benelux (the Netherlands), is a professor of radiology in the Division of MR Research and is director of the cellular imaging section at the Institute for Cell Engineering, Johns Hopkins University School of Medicine. In 1991, Dr. Bulte graduated summa cum laude in medicine/immunoloy from the University of Groningen, and he spent 10 years in the Laboratory of Diagnostic Radiology Research at the National Institutes of Health before moving to Hopkins in 2001. His research specializes in molecular and cellular MR imaging.
Bibliographische Angaben
- 2007, 440 Seiten, Englisch
- Herausgegeben: Michel M. J. Modo, Jeff W. M. Bulte
- Verlag: Taylor & Francis
- ISBN-10: 1420004093
- ISBN-13: 9781420004090
- Erscheinungsdatum: 28.03.2007
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