Molecular and Biochemical Toxicology (PDF)

An essential resource for graduate students, academic andindustrial toxicologists, and environmental health scientists andprofessionals

Over the course of thirty years and three editions,Introduction to Biochemical Toxicology has been an importantsource for coverage of the ongoing quest to define the biochemical,cellular, and molecular events induced by toxicants at the cellularand organismic levels. Now, as the principles and methods ofmolecular and cellular biology as well as genomic sciences play anever increasing role in mechanistic toxicology, significant changeshave been made to the book, resulting in this important newedition-now titled Molecular and Biochemical Toxicology,Fourth Edition.

Much more than an introductory text, this crucial new editionhas been completely revised to provide timely and thorough coverageof the underlying biochemical, molecular, and cellular mechanismsthrough which toxicants produce their adverse effects.Toxicological issues are covered from the molecule to the cell tothe organ level. Complex methods used in toxicology are alsodescribed in a straightforward, easy-to-understand style.Additional features of this new edition include:
* New chapters that explore the interface between toxicology andgenomic sciences, including: bioinformatics, proteomics,metabolomics, and toxicogenomics
* Increased emphasis on structure, mechanism, and regulation ofxenobiotic metabolizing enzymes, toxicogenetics, and xenobiotictransporters
* Additional new chapters on: molecular epidemiology and geneticsusceptibility, DNA damage and mutagenesis, DNA repair, mechanismsof cell death, mitochondrial dysfunction, metals, reproductivetoxicology, developmental toxicology, and reactiveoxygen/metabolites and toxicity

Molecular and Biochemical Toxicology, Fourth Editionguides graduate students, toxicologists, and environmental healthprofessionals through the principles of molecular and biochemicaltoxicology and the complex mechanisms of toxicity. Whether it'sused in the classroom or in industry, research, or academia, thisbook is essential for anyone interested in understanding themolecular mechanisms through which toxicants produce adverseeffects.