Electrospray and MALDI Mass Spectrometry (PDF)

Discover how advances in mass spectrometry are fueling new
discoveries across a broad range of research areas

Electrospray and MALDI Mass Spectrometry brings both veteran
practitioners and beginning scientists up to date with the most
recent trends and findings in electrospray ionization and
matrix-assisted laser desorption/ionization (MALDI) mass
spectrometry. In particular, this Second Edition highlights how
advances in electrospray and MALDI mass spectrometry are supporting
important discoveries in new and emerging fields such as proteomics
and metabolomics as well as in traditional areas of chemistry and
physics research.

Electrospray AND MALDI Mass Spectrometry, SECOND EDITION is
divided into five parts:

* Part A, Fundamentals of ES, explains the fundamental phenomena
underlying the electrospray process, including selectivity in
ionization and inherent electrochemistry, and concludes with a
chapter offering a comparative inventory of source hardware

* Part B, Fundamentals of MALDI, confronts ionization mechanisms,
instrument development, and matrix selection, and includes a final
chapter that explores the special application of MALDI to obtain
two-dimensional images of spatial distributions of compounds on
surfaces

* Part C, ES and MALDI Coupling to Mass Spectrometry
Instrumentation, examines the coupling of these ionization
techniques to various mass analyzers, including quadrupole ion
trap, time-of-flight, Fourier transform ion cyclotron resonance,
and ion mobility mass spectrometers

* Part D, Practical Aspects of ES and MALDI, investigates
analytical issues including quantification, charge-state
distributions, noncovalent interactions in solution that are
preserved as gas-phase ions, and various means of ion excitation in
preparation for tandem mass spectrometry, and offers a guide to the
interpretation of even-electron mass spectra

* Part E, Biological Applications of ES and MALDI, examines the
role of mass spectrometry in such areas as peptide and protein
characterization, carbohydrate analysis, lipid analysis, and drug
discovery

Written by a team of leading experts, the book not only provides
a critical review of the literature, but also presents key concepts
in tutorial fashion to help readers take full advantage of the
latest technological breakthroughs and applications. As a result,
Electrospray and MALDI Mass Spectrometry will help researchers
fully leverage the power of electrospray and MALDI mass
spectrometry. The judicious compartmentalization of chapters, and
the pedagogic presentation style throughout, render the book highly
suitable for use as a text for graduate-level courses in advanced
mass spectrometry.