Chirality in Drug Research / Methods and Principles in Medicinal Chemistry Bd.33 (PDF)
(Sprache: Englisch)
Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.
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Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Inhaltsverzeichnis zu „Chirality in Drug Research / Methods and Principles in Medicinal Chemistry Bd.33 (PDF)“
INTRODUCTION Chiral drugs from a historical point of view (J. Gal) SYNTHESIS Stereoselective synthesis of chiral drugs (H. Federsel) Chiral drugs from natural source (F. Petersen) Biotransformation methods for preparing chiral drugs and drug intermediates (M. Müller, M. Wubbolts) SEPARATIONS Resolution of chiral drugs and drug intermediates by crystallisation (K. Saigo) Resolution of chiral drugs by preparative chromatography (E. Francotte) ANALYSIS Stereoselective chromatographic methods for drug analysis (W. Lindner) CE-MS for the quantitative analysis of chiral drugs (J. Veuthey) Spectrosopic methods for chiral drug analysis (N. Harada) Modeling of chiral drug-receptor interactions (G. Folkers)
Autoren-Porträt
Eric Francotte received his BS and PhD degrees from the University of Louvain (Belgium). After postdoctoral work at the University of Geneva, he joined the Central Research Laboratories at Ciba-Geigy, where he was working on optically active polymers. He is now Director and Head of Separations at the Novartis Institutes for BioMedical Research in Basel (Switzerland). He is also an editor of the Wiley journal "Chirality". His major interests include development and applications of chiral stationary phases for the separation of stereoisomers on an analytical and preparative scale. Wolfgang Lindner received his PhD degree in Organic Chemistry from the University of Graz (Austria). After several academic positions, including a period at the FDA in Bethesda (USA), he was appointed the chair in Analytical Chemistry at the University of Vienna (Austria). He is also the editor of the Journal of Chromatography B, and the current president of the Austrian Society of Analytical Chemistry. His major interests lie in enantioselective separation techniques, including LC, CE, membranes, extractions, and in stereoselective pharmacokinetics.
Bibliographische Angaben
- 2007, 1. Auflage, 351 Seiten, Englisch
- Herausgegeben: Eric R. Francotte, Wolfgang Lindner
- Verlag: Wiley-VCH GmbH
- ISBN-10: 3527608710
- ISBN-13: 9783527608713
- Erscheinungsdatum: 24.09.2007
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