Carbonic Anhydrase as Drug Target (PDF)
Thermodynamics and Structure of Inhibitor Binding
(Sprache: Englisch)
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in...
sofort als Download lieferbar
eBook (pdf)
Fr. 118.00
inkl. MwSt.
- Kreditkarte, Paypal, Rechnung
- Kostenloser tolino webreader
Produktdetails
Produktinformationen zu „Carbonic Anhydrase as Drug Target (PDF)“
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design. X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes. They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy. In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail. Also typesand chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
Autoren-Porträt
Prof. Dr. Daumantas MatulisVilnius University
Life Sciences Center
Institute of Biotechnology
Department of Biothermodynamics and Drug Design
Sauletekio 7, 10257 Vilnius
Lithuania
Bibliographische Angaben
- 2019, 1st ed. 2019, 353 Seiten, Englisch
- Herausgegeben: Daumantas Matulis
- Verlag: Springer-Verlag GmbH
- ISBN-10: 303012780X
- ISBN-13: 9783030127800
- Erscheinungsdatum: 21.05.2019
Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.
eBook Informationen
- Dateiformat: PDF
- Grösse: 18 MB
- Ohne Kopierschutz
- Vorlesefunktion
Sprache:
Englisch
Kommentar zu "Carbonic Anhydrase as Drug Target"
0 Gebrauchte Artikel zu „Carbonic Anhydrase as Drug Target“
| Zustand | Preis | Porto | Zahlung | Verkäufer | Rating |
|---|
Schreiben Sie einen Kommentar zu "Carbonic Anhydrase as Drug Target".
Kommentar verfassen