Biochemical Engineering (PDF)

PART I: Basic Concepts and Principles INTRODUCTION Background and Scope Dimensions and Units Intensive and Extensive Properties Equilibria and Rates Batch vs. Continuous Operation Material Balance Energy Balance ELEMENTS OF PHYSICAL TRANSFER PROCESSES Introduction Heat Conduction and Molecular Diffusion Fluid Flow and Momentum Transfer Laminar vs. Turbulent Flow Transfer Phenomena in Turbulent Flow Film Coefficients of Heat and Mass Transfer CHEMICAL AND BIOCHEMICAL KINETICS Introduction Fundamental Reaction Kinetics CELL KINETICS Introduction Cell Growth Growth Phases in Batch Culture Factors Affecting Rates of Cell Growth Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF) PART II: Unit Operations and Apparatus for Bio-Systems HEAT TRANSFER Introduction Overall Coefficients U and Film Coefficients h Mean Temperature Difference Estimation of Film Coefficients h Estimation of Overall Coefficients U MASS TRANSFER Introduction Overall Coefficients K and Film Coefficients k of Mass Transfer Types of Mass Transfer Equipment Models for Mass Transfer at the Interface Liquid Phase Mass Transfer with Chemical Reactions Correlations for Film Coefficients of Mass Transfer Performance of Packed Column BIOREACTORS Introduction Some Fundamental Concepts Bubbling Gas-Liquid Reactors Mechanically Stirred Tanks Gas Dispersion in Stirred Tanks Bubble Columns Airlift Reactors Packed-Bed Reactors Microreactors MEMBRANE PROCESSES Introduction Dialysis Ultrafiltration Microfiltration Reverse Osmosis Membrane Modules CELL-LIQUID SEPARATION AND CELL DISRUPTION Introduction Conventional Filtration Microfiltration Centrifugation Cell Disruption STERILIZATION Introduction Kinetics of Thermal Death of Cells Batch Heat Sterilization of Culture Media Continuous Heat Sterilization of Culture Media Sterilizing Filtration ADSORPTION AND CHROMATROGRAPHY Introduction Equilibria in Adsorption Rates of Adsorption into Adsorbent Particles Single- and Multi-Stage Processes for

Prof. Shigeo Katoh is Head of the Bioengineering Laboratory at Kobe University, Japan. He holds PhD in Chemical Engineering from the University of Kyoto, Japan. Prof. Katoh is an enthusiastic lecturer in Biochemical Engineering, Bioseparation Engineering and Immunotechnology. He is an outstanding expert in biochemical engineering and has published numerous papers in this field.

Prof. em. Fumitake Yoshida was one of the world's most respected chemical engineers. Most recently he was professor emeritus of chemical engineering at Kyoto University and well beyond his retirement he continued to be a visiting lecturer at universities around the world. He conducted research on various mass transfer operations, gas-liquid systems in particular, investigating their applications in bioengineering and medical technology. Yoshida received his BS and PhD degrees in engineering from Kyoto University. Among his many awards and citations was election to the National Academy of Engineering of the United States in 1979 for his leadership in chemical, biochemical, and biomedical engineering in Japan.

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