Viral Genome Replication
(Sprache: Englisch)
This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.
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Produktinformationen zu „Viral Genome Replication “
This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.
Klappentext zu „Viral Genome Replication “
Currently,there is no single source that permitscomparisonof the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our parti- lar system,missing outon theopportunityto de neunifyingthemesin viralgenome replication or bene t from the advances in other systems. For example, extraor- nary biologicaland experimentalparadigmsthat have been established overthe past 5 years for the DNA replication systems of bacteriophage T4 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the eld, as well as encourage students into this area of research. The monograph has been divided into eight parts. Chapters appearing in Parts I-VI are intended to compare and contrast the replication and/or transcription processes and corresponding "players" of the indicated family of viruses. We are interested in the sequence of events that lead to production of mRNA and progeny genomes as well as the cis-acting elements and trans-acting factors and enzymes (viral and cellular) that are required for these processes. Chapters appearing in Part VII are - tended to providea more biochemical and biophysicalperspective of the replication and/ortranscriptionprocess. Chaptersappearingin Part VIII are intendedto provide a practical perspective on viral replication and its inhibition.
Viruses are responsible for a variety of human, animal, and plant diseases and now represent potential agents of terror. Academic, government, and corporate laboratories have devoted years of effort to the development of strategies to prevent or treat viral infections. Central to the multiplication strategy of all viruses is the process of genome replication. Enzymes critical to this step of the lifecycle have proven to be tractable targets targets for the development of antiviral agents. Furthermore, genome replication is essential for virus spread and is the main target for the development of antiviral agents. By combining studies of both RNA and DNA viruses - and more - into a single volume, the editors have created a mechanism for cross-talk between the fields that will produce synergy and could lead to more rapid discovery of approaches to treat viral infections.
Inhaltsverzeichnis zu „Viral Genome Replication “
- Genome replication strategies- plus-strand RNA viruses
- Model of Picornavirus RNA Replication
- Coronavirus Genome Replication
- Flaviviruses
- Hepatitis C virus genome replication
- Brome mosaic virus RNA replication and transcription
- Retroviruses
- Hepadnaviral genomic replication
- minus-strand RNA viruses
- Orthomyxoviruses genome transcription and replication
- ambisense RNA viruses
- Arenaviruses: Genome replication strategies
- dsRNA viruses
- Core-associated genome replication mechanisms of dsRNA viruses
- DNA viruses
- Poxviruses
- Herpesevirus genome replication
- Host factors
- Host factors promoting replication
- Host factors that restrict retrovirus replication
- Elements, factors and enzymes: Structure-function and mechanism
- T4 Phage Replisome
- Atomic structure of the Herpes Simplex Virus 1 DNA polymerase
- RNA virus polymerases
- Human immunodeficiency virus reverse transcriptase
- Viral helicases
- Integrase: structure, function and mechanism
- Antivirals: Targets, mechanisms and resistance
- Viral DNA polymerase inhibitors
- RNA polymerase inhibitors
- HIV reverse transcriptase inhibitors and mechanisms of resistance
- Lethal mutagenesis
- Clinical implications of reverse transcriptase inhibitor resistance
Bibliographische Angaben
- 2009, 656 Seiten, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Craig E. Cameron, Kevin Raney, Matthias Gotte
- Verlag: Springer US
- ISBN-10: 038789425X
- ISBN-13: 9780387894256
- Erscheinungsdatum: 21.07.2009
Sprache:
Englisch
Rezension zu „Viral Genome Replication “
From the reviews: "Viruses are primarily classified by the structure of their genomes. ! they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. ! the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. ! I recommend this title to all those interested in viral replication." (Christopher Ring, Microbiology Today, November, 2009)
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