Translational Toxicology

I.Introduction.- The Opportunity to Translate Developmental Toxicology into a Therapeutic Discipline.- TheRole of Toxicokinetics and Toxicodynamics in Developmental and TranslationalToxicology.- II.Toxicant Modes of Action and Biomarkers.- Mutational Effects.- Ligand-Mediated Toxicology: Characterization and Translational Prospects.- Effects of Environmentally Acquired Heavy Metals and Nutrients on the Epigenome and Phenotype.- Fetal Imaging and Effects of Exposures on Growth and Function.- III.Developmental Risks of Exposures and Potential Translational Toxicology Therapeutics.- Ovarian Toxicity of Environmental Contaminants: 50 Shades of Grey.- The"Toxic" Effects of a Perinatal Obesogenic Environment: Maternal Obesity andImpacts on Future Generations.- The Role of Environmental Exposures in Preterm Birth.- The Impact of Environmental Stressors on DNA Methylation, Neurobehavioral Development and Chronic Physical Aggression: Prospects for Early Protective Interventions.- Coffee Health Effects from Early Fetal Development through Childhood and Adolescence.

Claude L. Hughes, M.D., Ph.D. is Executive Director in the Therapeutic Science & Strategy Unit within Quintiles Inc. He is board-certified in Obstetrics & Gynecology and Reproductive Endocrinology and Infertility. He is a Consulting Professor in the Department of Obstetrics & Gynecology, Duke University Medical Center and an Adjunct Professor in the Department of Mathematics, North Carolina State University and in the Department of Pathology/Comparative Medicine, Wake Forest University School of Medicine.
Since joining Quintiles in 2001, Dr. Hughes has served as a Medical Advisor on clinical trials or in due diligence assessment teams that evaluated pharmaceuticals, devices or tests for several medical indications. Therapeutic areas for clinical trials and/or product evaluation have included the following: 1) Reproductive Medicine - female sex hormone therapy, male sex hormone therapy, contraception, infertility, in vitro fertilization-embryo transfer, polycystic ovary syndrome, SERMs, overactive bladder/urinary incontinence, endometriosis, preterm labor, ovarian cancer, cervical cancer, microbicides, dysmenorrhea, gynecologic infections, female and male sexual dysfunction, erectile dysfunction, BPH/LUTS, delayed puberty in boys, primary and secondary hypogonadism in boys.2) General Endocrinology, Metabolism and Cardiovascular Diseases - osteoporosis prevention and treatment, diabetes mellitus, thyroid hormone replacement, growth hormone therapy in children, hypertension (including use of ambulatory blood pressure monitoring - ABPM) and chronic renal disease.3) Other Medical Conditions - GERD, opioid-induced constipation, rheumatoid arthritis, sleep disorders, migraine headaches, neuropathic pain and psoriasis. 4) Laboratory Testing Methods - genital cytologic screening and molecular biomarker screening.5) Drug Delivery - new systems for transdermal, buccal or vaginal administration of drugs.
Prior to joining Quintiles, Dr.