The Local Cardiac Renin-Angiotensin Aldosterone System
(Sprache: Englisch)
Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms...
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Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system.
Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest.
Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION.
Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.
Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest.
Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION.
Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.
Klappentext zu „The Local Cardiac Renin-Angiotensin Aldosterone System “
Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system.Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest.
Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION.
Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.
Within the classic renin-angiotensin endocrine system, the enzyme renin is produced in the kidney and upon stimulation for its release, it acts upon circulating angiotensinogen which is produced in the liver. The resultant decapeptide angioteinsin I loses its terminal two peptides upon its circulation through the lung by the angiotensin converting enzyme to form the powerful pressor decapeptide angiotensin II which promotes potent vasoconstriction, stimulates the release of aldosterone from the adrenal gland and, in turn, the retention of sodium and water by the kidney.
Until recently, there has been much research concerning local renin angiotensin systems functioning within such organs as the heart, blood vessels, kidney, brain, and others. In addition, research has shown that some of these organs also seem to produce locally the steroidal hormone aldosterone. This very important area of research has now achieved major clinical attention because these local systems seem to account for such major biological actions as mitogenesis, cellular hypertrophy, fibrosis, apoptosis, and inflammation within those organs. Moreover, further research has demonstrated still more complicated aspects to the metabolic events associated with the cascade of hormonal substances that result from the biogenesis of the angiotensins. The clinical implications of these events are of great clinical significance and also important pathophysiologically and therapeutically.
Until recently, there has been much research concerning local renin angiotensin systems functioning within such organs as the heart, blood vessels, kidney, brain, and others. In addition, research has shown that some of these organs also seem to produce locally the steroidal hormone aldosterone. This very important area of research has now achieved major clinical attention because these local systems seem to account for such major biological actions as mitogenesis, cellular hypertrophy, fibrosis, apoptosis, and inflammation within those organs. Moreover, further research has demonstrated still more complicated aspects to the metabolic events associated with the cascade of hormonal substances that result from the biogenesis of the angiotensins. The clinical implications of these events are of great clinical significance and also important pathophysiologically and therapeutically.
Inhaltsverzeichnis zu „The Local Cardiac Renin-Angiotensin Aldosterone System “
Are Local Renin-Angiotensin Systems the Focal Points for Understanding Salt Sensitivity in Hypertension?.- Newer Insights into the Biochemical Physiology of the Renin-Angiotensin System: Role of Angiotensin-(1-7), Angiotensin Converting Enzyme 2, and Angiotensin-(1-12).- Renin, Prorenin, and the (Pro)renin Receptor.- Intracellular Accumulation and Nuclear Trafficking of Angiotensin II and the Angiotensin II Type 1 Receptor.- Pathophysiologic Implications of Cell Swelling in the Failing Heart: Influence of Intracrine and Extracellular Renin-Angiotensin Systems.- Exploiting Rat Genetics to Investigate Hypertensive End-Organ Damage.- Alternative Renin Transcripts and Functions of Cytoplasmatic Renin.- Novel Aspects of the Cardiac Renin-Angiotensin System.- Intracrine Function from Angiotensin to Stem Cells.- Renin Cell Identity and Homeostasis.- Role of Renal Aminopeptidases and Angiotensin Type-2 (AT2) Receptors in Sodium Excretion and Hypertension.- Intrarenal Angiotensin II Augmentation in Hypertension.- Collecting Duct Renin: A Critical Linkin Angiotensin II-Dependent Hypertension.- Renin-Angiotensin-Aldosterone System and Cardiomyocyte Apoptosis in Hypertensive Heart Disease.- Upregulation of Angiotensin II Type 2 Receptor (agtr2) Attenuates Atherosclerotic Lesion Formation and Enhances Apoptosis in the LDL Receptor Knockout Mice Fed High Cholesterol Diet.- Salt and Heart: RAAS Involvement.- Cardiac Effects of Aldosterone, the Bad, but Is There Also a Good?.
Bibliographische Angaben
- 2009, 2. Aufl., XII, 184 Seiten, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Edward D. Frohlich, Richard N. Re
- Verlag: Springer, Berlin
- ISBN-10: 1441905278
- ISBN-13: 9781441905277
- Erscheinungsdatum: 25.09.2009
Sprache:
Englisch
Rezension zu „The Local Cardiac Renin-Angiotensin Aldosterone System “
From the reviews of the second edition:"This book disseminates new findings about the local renin-angiotensin aldosterone system (RAAS) in the cardiovascular system and the kidneys ... . This is a great resource for anyone doing research into any cell or tissue that is regulated or potentially regulated by RAAS. ... Students beginning careers in research in this field will find this to be a great account of current research ... . As a gastrointestinal physiologist with a long-time interest in hormonal regulation of cell function, I found this book intriguing." (David L. Osborne, Doody's Review Service, June, 2010)
Pressezitat
From the reviews of the second edition: "This book disseminates new findings about the local renin-angiotensin aldosterone system (RAAS) in the cardiovascular system and the kidneys ... . This is a great resource for anyone doing research into any cell or tissue that is regulated or potentially regulated by RAAS. ... Students beginning careers in research in this field will find this to be a great account of current research ... . As a gastrointestinal physiologist with a long-time interest in hormonal regulation of cell function, I found this book intriguing." (David L. Osborne, Doody's Review Service, June, 2010)
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