The Human T-Cell Receptor Repertoire and Transplantation
(Sprache: Englisch)
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8...
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Klappentext zu „The Human T-Cell Receptor Repertoire and Transplantation “
these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. - -- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
Inhaltsverzeichnis zu „The Human T-Cell Receptor Repertoire and Transplantation “
1. General Introduction.- 2. The Circulating Human Peripheral T-Cell Repertoire.- 3. T Cell Receptor Usage in Alloreactivity.- 4. T-Cell Receptor Usage Among Graft Infiltrating T Lymphocytes.- 5. T-Cell Receptor V Gene Usage in T-Cell Lines Propagated from Graft-Infiltrating T Lymphocytes in Needle Biopsies of Rejecting Renal Allografts.- 6. Structure of T Cell Receptor V? and V? Chains Expressed by T-Lymphocytes in Cardiac Allograft Derived Cell Lines.- 7. Involvement of Minor Histocompatability Antigens in the Rejection of an HLA Identical Renal Transplant from a Living Related Donor.- 8. Concluding Remarks.
Bibliographische Angaben
- 2013, Softcover reprint of the original 1st ed. 1995, XI, 173 Seiten, Masse: 17,8 x 25,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Peter van den Elsen
- Verlag: Springer, Berlin
- ISBN-10: 3662224968
- ISBN-13: 9783662224960
Sprache:
Englisch
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