The Biogenesis of Cellular Organelles

Preface 1. Theory of Organelle Biogenesis: A Historical Perspective; Barbara M. Mullock and J. Paul Luzio.- Definitions.- The History of Organelle Recognition.- Protein Synthesis and Targeting.- Organization into Complex Structures.- Organelle Inheritance.-Challenges.- 2. Protein Coats As Mediators of Intracellular Sorting and Organelle Biogenesis; Chris Mullins.- Clathrin: A Scaffold for Protein Coats.- Adaptor Protein Complexes: Adaptors for Coats of the Late-Secretory and Endocytic Pathways.- COP Complexes: Protein Coats of the Early Secretory Pathway.- Adaptor-Related Proteins Define Novel Coats of the Secretory and Endocytic Pathways.- 3. The Role of Proteins and Lipids in Organelle Biogenesis in the Secretory Pathway; Thomas F. J. Martin.- Protein Sorting Confers a Transient Nature to Secretory Pathway Organelles.- The Molecular Machinery Regulating Compartment Identity.- General Mechanisms Employed for Cargo Exit and Entry: Fission and Fusion.- Exit Mechanisms in Trafficking.- Entry Mechanisms in Trafficking: Tethering, Priming and Fusion.- 4. Endoplasmic Reticulum Biogenesis: Proliferation and Differentiation; Erik Snapp.- ER Functions.- Building Blocks of the ER.- ER Biogenesis.- ER Network Formation.- ER Subdomains.- ER Differentiation.- Putting It All Together. Appendices.- 5. The Golgi Apparatus: Structure, Function and Cellular Dynamics; Nihal Altan-Bonnet and Jennifer Lippincott-Schwartz.- Golgi Structure and Distribution.- Golgi Function and Compartmentalization.- Transport within the Golgi Complex.- Golgi Dynamics: Interphase.- Golgi Dynamics: Mitosis.- Golgi As a Scaffold for Signaling Molecules.- 6. Lysosome Biogenesis and Dynamics; Diane McVey Ward, Shelly L. Shiflett and Jerry Kaplan.- Models for Lysosome Biogenesis.- Synthesis and Delivery of Lysosomal Hydrolases.- Synthesis and Trafficking of Lysosomal Membrane Proteins.- Lysosomes and Endosomes Undergo Fusion and Fission.- Lysosomes Are Capable of Fusion with the Plasma Membrane.- Movement of