Stress Proteins
(Sprache: Englisch)
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With contributions by numerous experts
Klappentext zu „Stress Proteins “
This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.
Inhaltsverzeichnis zu „Stress Proteins “
1 Stress Proteins: An Overview.- A. Introduction.- B. The Stress Proteins.- C. Functions of Stress Proteins.- D. Hsp Expression and Regulation.- E. Stress Proteins and Protection.- F. Stress Proteins and Human Disease.- G. Conclusion.- 2 The Hsp90 Chaperone Family.- A. General Aspects.- B. The Early Protein Folding Complex.- C. Hsp90-Containing Multimolecular Complexes.- I. The Steroid Receptor-Associated Hsp90-Containing Intermediate Folding Complex.- II. The Steroid Receptor-Associated Hsp90-Containing Mature Folding Complex.- D. Individual Chaperone and Co-chaperone Proteins Found in Hsp90 Complexes.- I. Hsp70.- II. p48Hip.- III. p60Hop.- IV. p23.- V. Immunophilins.- VI. Other TPR-Containing Proteins.- VII. p50Cdc37.- E. Refolding of Denatured Proteins.- F. Benzoquinone Ansamycins and Nucleotide Binding to Hsp90.- G. Hsp90 Client Proteins.- I. Transcription Factors.- 1. Steroid Receptors.- 2. Aryl Hydrocarbon Receptor.- 3. Mutated p53.- 4. Heat Shock Factor.- II. Protein Kinases.- 1. Tyrosine Kinases.- a) The Src Family Kinases.- b) Weel Kinase.- c) Sevenless Tyrosine Kinase.- d) Receptor Tyrosine Kinases - pl85erbB2.- 2. Serine/Threonine Kinases.- a) Raf-1 Kinase.- b) Casein Kinase II.- c) Heme-Regulated eIF-2? Kinase (HRI).- d) Cdk4/Cdk6.- III. Other Proteins.- 1. Cytoskeletal Proteins.- 2. Calmodulin.- 3. ss?-Subunits of Trimeric GTP-Binding Proteins.- 4. Proteasome.- 5. Hepadnavirus Reverse Transcriptase.- 6. Tumor Necrosis Factor Receptor and Retinoblastoma Protein.- H. Hsp90 and Drug Development.- I. Conclusion.- References.- 3 Heat Shock Protein 70.- A. Introduction.- B. Expression and Function of hsp70.- I. Hsp70, Transient Thermotolerance and Permanent Heat Resistance.- II. Hsp70 and Apoptosis.- III. Hsp70 Protects Cells from Oxidative Stress.- IV. Hsp70 Protects Cells from X-Ray Damage.- V. Hsp70 as Molecular Chaperone.- C. Regulation of hsp70.- I. Heat Shock Transcription Factor (HSF), the Transcriptional Regulator of hsp70.- II Signal Transduction
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Leading to Modulation of hsp70 Levels.- III. Negative Regulatory Effect of ERK1 on hsp70 Gene Expression.- IV. Mutational Analysis of HSF-1 Phosphorylation by ERK1 Protein Kinase.- V. Modulation of HSF-1 by Other Protein Kinases.- VI. Implication of HSF-1 Regulation by Functionally Opposing Signaling Cascades.- VII. Regulation of Heat Shock Response: Possible Involvement of Ku Autoantigen.- References.- 4 Mitochondrial Molecular Chaperones hsp60 and mhsp70: Are Their Roles Restricted to Mitochondria?.- A. Introduction.- B. Structure and function.- I. Studies with Purified Proteins.- 1. Hsp70/DnaK.- 2. Hsp60/GroEL.- II. In Vivo and Mitochondrial Systems.- C. Are hsp60 and mhsp70 Restricted to Mitochondria?.- I. Subcellular Localization: The Unexplained Findings.- II. Consideration of Possible Artifacts.- III. Possible Extramitochondrial Functions.- IV. Proposed Transport Mechanisms.- D. Hsp60 in Drug Resistance and Disease.- E. Future Prospects.- References.- 5 Role of Hsp27 and Related Proteins.- A. Introduction.- B. sHsp Genes and Control of Their Expression.- I. The Family of SHsp and the Structure of the Genes Encoding These Proteins.- II. Regulation of the Expression of sHsp Genes by Heat Shock.- III. Regulation of the Constitutive and Hormone-Dependent Expression of sHsp Genes.- IV. Tissue-Specific sHsp Expression During Development and in Adult Organisms.- V. Specific sHsp Expression During Early Differentiation.- VI. Pathological sHsp Expression and Associated Diseases.- C. Biochemical Properties of sHsp.- I. Structural Organization of sHsp.- II. Quaternary Structure of sHsp.- III. Phosphorylation of sHsp.- IV. Cellular Localization of sHsp.- D. Functions of sHsp.- I. sHsp Expression Induces Thermotolerance and Protects Cytoskeletal Architecture.- II. sHsp Act as Protein Chaperones.- III. sHsp Protection Against TNF and Oxidative Stress Inducers.- IV. sHsp Expression Protects Against Apoptosis.- 1. sHsp Interfere with In Vitro-Mediated Apoptosis.- 2. sHsp as
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Bibliographische Angaben
- 2012, 422 Seiten, 4 farbige Abbildungen, Masse: 15,5 x 23,5 cm, Kartoniert (TB), Englisch
- Herausgegeben: David S. Latchman
- Verlag: Springer, Berlin
- ISBN-10: 3642635199
- ISBN-13: 9783642635199
Sprache:
Englisch
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