Purification of Peptides in High-Complexity Arrays
A New Method for the Specific Surface Exchange and Purification of Entire Peptide Libraries
(Sprache: Englisch)
This book outlines an improvement of the quality of in situ synthesized high-complexity peptide micro arrays. It details the development of a new method allowing for fast one-step purification of entire arrays without loss of resolution or spatial information.
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This book outlines an improvement of the quality of in situ synthesized high-complexity peptide micro arrays. It details the development of a new method allowing for fast one-step purification of entire arrays without loss of resolution or spatial information.
Klappentext zu „Purification of Peptides in High-Complexity Arrays “
Christopher Schirwitz's thesis focuses on improving the quality of in situ synthesized high-complexity peptide micro arrays. Micro arrays containing proteins or small protein fragments in the form of peptides have become of great interest in proteomic research.With the help of these microarrays a large number of potential target molecules can be screened for interaction with a probe in a short timeframe. However, protein and peptide
micro arrays are still lagging behind oligonucleotide arrays in terms of density, quality and manufacturing costs. A new approach developed at the German Cancer Research
Center (DKFZ) has improved the synthesis of high-density peptide arrays. The current technology is capable of producing arrays with up to 40,000 different peptides per square cm by means of micro particle-based solid phase peptide synthesis. However, in situ synthesis approaches bear a conceptual disadvantage: The quality of the peptides is dependent on the efficiency of the synthesis so that peptide fragments are present in the resulting array among the desired full-length peptides. In peptide-protein interaction studies such peptide fragments. The central achievement of this thesis is the development of a new method allowing for the fast one-step purification of entire
arrays without loss of resolution or spatial information. Christopher Schirwitz's work has resulted in a number of publications in high ranking journals.
Inhaltsverzeichnis zu „Purification of Peptides in High-Complexity Arrays “
Introduction.- Concept & State-of-the-Art.- Results & Discussion.- Conclusion.- Materials & Methods.
Bibliographische Angaben
- Autor: Christopher Schirwitz
- 2013, 2013, XIII, 132 Seiten, 53 farbige Abbildungen, Masse: 16,2 x 24,2 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3319008064
- ISBN-13: 9783319008066
Sprache:
Englisch
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