Preparative Chromatography

INTRODUCTION FUNDAMENTALS AND GENERAL TERMINOLOGY Principles of Adsorption Chromatography Basic Effects and Chromatographic Definitions Equilibrium Thermodynamics Fluid Dynamics Mass Transfer Phenomena References STATIONARY PHASES AND CHROMATOGRAPHIC SYSTEMS Column Packings Selection of Chromatographic Systems References CHROMATOGRAPHY EQUIPMENT: ENGINEERING AND OPERATION Introduction Challenges for Conceptual Process Design Engineering and Operational Challenges Commercial Chromatography Column Commercial Chromatography Systems Standard Process Control Packing Methods Process Troubleshooting Disposable Technology for Bio-separations References PROCESS CONCEPTS Discontinuous Processes Continuous Processes Choice of Process concepts References MODELING AND MODEL PARAMETERS Introduction Models for Single Chromatographic Columns Modeling HPLC Plants Calculation Methods Parameter Determination References MODEL BASED DESIGN, OPTIMIZATION AND CONTROL Basic Principles and Definitions Isocratic Batch Chromatography Gradient Batch Chromatography Recycling Chromatography Conventional Isocratic SMB Chromatography Isocratic SMB Chromatography under Variable Operating Conditions Gradient SMB Chromatography Practical Approaches for Design of SMB Chromatography Process Configuration and Optimization by Superstructures Advanced Process Control References

Professor Schmidt-Traub was Professor for Plant and Process Design at the Department of Biochemical and Chemical Engineering, University of Dortmund, Germany until his retirement in 2006. He is still active in the research community and his main areas of research focus on preparative chromatography, down stream processing, integrated processes, plant design and innovative energy transfer. Prior to his academic appointment, Prof. Schmidt-Traub gained 15 years of industrial experience in plant engineering. Prof. Seidel-Morgenstern is the Director of the Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg, Germany and holds the Chair in Chemical Process Engineering at the Otto-von-Guericke-Universität, Magdeburg, Germany. He received his Ph.D. in 1987 at the Institute of Physical Chemistry of the Academy of Sciences in Berlin. From there he went on to work as postdoctoral fellow at the University of Tennessee, Knoxville, USA. In 1994 he finished his habilitation at the Technical University in Berlin. His research is focused on new reactor concepts, chromatographic reactors, membrane reactors, adsorption and preparative chromatography and separation of enantiomers amongst others. Dr. Michael Schulte is Senior Director Emerging Businesses Energy at Merck KGaA Performance Materials, Darmstadt, Germany. In his Ph.D. thesis at the University of Münster, Germany, he developed new chiral stationary phases for chromatographic enantioseparations. In 1995 he joined Merck and has since then been responsible for research and development in the area of preparative chromatography, including the development of new stationary phases, new separation processes and the implementation of Simulated Moving Bed-technology at Merck. In his current position one of his areas of research is the use of Ionic Liquids for separation processes.

"I would not hesitate to recommend it to anyone working in this field."
Chromatographia
 
"Overall the coverage is a bit uneven - nevertheless the volume does compile some useful material... In conclusion, this is a comprehensive reference text, which should find its way into the libraries of all companies who are serious about process scale preparative chromatography, whether internally or via outsource contracts."
Organic Process Research and Development
 
"This special volume is essential for chemists and engineers working in chemical and pharmaceutical industries, as well as for food technologies, due to the interdisciplinary nature of these preparative chromatographic processes."
Advances in Food Sciences