Oral Anticoagulation Therapy

Table of Contents

Part I Introduction
1

Part II Atrial Fibrillation
2: CHA2DS2VASc and HAS-BLED risk stratification tools
3: Male with priority of ischemic stroke reduction
4: Choosing an anticoagulant in an elderly patient
5: Patient with prior history of gastrointestinal hemorrhage
6: Patients with a history of intracranial hemorrhage
7: Concerns with anticoagulant adherence
8: Oral Anticoagulants in stable moderate Chronic Kidney Disease
9: Oral Anticoagulants in severe renal dysfunction
10: Oral Anticoagulants in patients with variable renal function
11: Patient with concomitant stable Coronary Artery Disease
12: Patient with concomitant acute venous thromboembolism
13: Patient with concomitant Mitral Valve Stenosis
14: Patient with concomitant Aortic Valve Stenosis

Part III Warfarin management
15: Best practices for switching from stable warfarin
16: Patient-centered strategies for improving warfarin management

Part IV Venous Thromboembolism (VTE)
17: Provoked versus unprovoked VTE
18: VTE prophylaxis in hip and knee replacement surgery
19: VTE prophylaxis in the intensive care unit
20: VTE and recent drug eluting stent placement
21: Acute VTE in a patient with moderate chronic kidney disease
22: Oral anticoagulation and duration in recurrent VTE
23: Pulmonary embolism (PE) with thrombolytic therapy

Part V Acute Coronary Syndrome (ACS)
24: Patient on oral anticoagulant presenting with ACS
25: Oral anticoagulant therapy post-percutaneous coronary intervention
26: ST-segment elevation myocardial infarction (lytic candidate) on oral anticoagulant
27: ACS with bypass surgery

Part VI Drug Interactions
28: Anticoagulant drug-drug interactions with CYP 3A4 inhibitors
29: Significance of P-glycoprotein (P-gp) drug-drug interactions
30: Considerations with pharmacodynamics drug-drug interactions
31: Management of direct oral anticoagulants with mixed P-gp/3A4

Katie Kiser, Pharm.D., BCACP received her Bachelor of Science in Biology from King University in Bristol, Tennessee and her Doctor of Pharmacy from the University of North Carolina School of Pharmacy in Chapel Hill, North Carolina. She completed her postgraduate year-one residency with emphasis in ambulatory care at Moses Cone Health System in Greensboro, North Carolina and her postgraduate year-tworesidency in ambulatory care at the University of North Carolina Hospitals in Chapel Hill, North Carolina. Dr. Kiser is faculty at South College School of Pharmacy in Knoxville, Tennessee and previously taught at the University of Maryland School of Pharmacy in Baltimore, Maryland.

Dr. Kiser has over 10 years of clinical and teaching experience in anticoagulation management and is a Board of Pharmaceutical Specialties certified Ambulatory Care Pharmacist. Dr. Kiser has practiced primarily in the outpatient clinical setting and served as the Director of the UHC Antithrombosis Clinic in Baltimore, Maryland from 2010 - 2014. Her current clinical practice is at NHC HealthCare in Farragut, Tennessee where she serves as a consultant pharmacist and specializes in oral anticoagulant management in a diverse rehabilitation and long term care population.

Dr. Kiser is an Associate Editor and co-founder of iForumRx.org which is an interactive web-based community designed to inform ambulatory care clinicians about high-quality, practice-changing evidence. Dr. Kiser is highly involved with the American College of Clinical Pharmacy and has served in local and national leadership positions She has written chapters in a leading pharmacy textbook and has participated in clinical research and written many peer-reviewed articles on anticoagulation, health literacy, the scholarship of teaching, and other topics.

"The purpose is to introduce cardiologists to several aspects of anticoagulation therapy, including pharmacotherapy and clinical management. ... This book is intended for practicing cardiologists and cardiology fellows. ... This is a high quality book. It is quite useful for its readability and for its illustrations. Compared to other similar books on this topic, this one is preferable because it is clearly written and highlights key points well." (Daniel Garcia, Doody's Book Reviews, August, 2017)