Nuclear Transport

The Structure and Composition of the Yeast NPC.- 1 Introduction.- 2 Overview of the Yeast NPC Structure.- 3 Yeast Nucleoporins: What's NUP, What's Not.- 4 The Yeast NPC as a Dynamic Structure.- 5 Putting It All Together: The Internal Organization of the Yeast NPC.- 6 Functional Environment of the Yeast NPC: The Interactions with Its Neighbors.- 7 Mechanism of Nucleocytoplasmic Transport.- References.- The Vertebrate Nuclear Pore Complex: From Structure to Function.- 1 Introduction.- 2 Toward the Three-Dimensional Architecture of the Nuclear Pore Complex.- 3 Molecular Constituents of the Nuclear Pore Complex: The Nucleoporins.- 4 What Is the Functional Significance of the Multiple Locations of Nucleoporins?.- 5 From Nuclear Pore Complex Structure to Nucleocytoplasmic Transport.- 6 Concluding Remarks.- References.- How Ran Is Regulated.- 1 Ran Belongs to the Superfamily of Ras-Related Proteins.- 2 Ran.- 3 Stimulation of Guanine Nucleotide Exchange by RanGEF.- 4 Induction of the Ran GTPase by RanGAP.- 5 Role of Ran in Protein Import.- 6 Effects of Importin-?-Related Proteins on the Activities of Ran.- 7 Recycling of Exported Import Factors by RanBP1/RanBP2.- 8 Export of Macromolecules from the Nucleus.- 9 Role of RanBP3 in Exportin-l-Mediated Export.- 10 Import of Ran into the Nucleus.- 11 Mogl Induces Release of GTP from Ran.- 12 RanGTP in Mitosis.- References.- Exportin-Mediated Nuclear Export of Proteins and Ribonucleoproteins.- 1 Introduction.- 2 Ran Is King.- 3 Exportins.- 4 CRM1/Exportin-1.- 5 Exportin-Mediated Export of Ribonucleoproteins.- 6 Exportin-4.- 7 Msn5/Exportin-5.- 8 Interaction of Exportins with the Nuclear Pore Complex.- 9 Perspectives.- References.- Structures of Importins.- 1 Introduction.- 2 NLS Recognition: Association with a.- 3 Cargo Bindingto the Receptor: Importin-?-Binding Association with ?.- 4 Cargo Release: RanGTP Binding to ? and ?2.- 5 Nuclear Pore Complex Docking.- 6 From Static Snapshots to a Dynamic Picture.- Addendum.- References.-