Neurodegenerative Disorders as Systemic Diseases

PART I A NEW CONCEPT OF NEURODEGENERATION IN BIOLOGY AND PATHOPHYSIOLOGY.- 1 Conformational disease and RNA disease theory in the context of neurodegenerative diseases.- 2 Brain-peripheral organ communication.- 3 The brain-immune network in spinal cord injury.- PART II CHANGES IN CLINICAL EVALUATION AND NEW BIOMARKERS.- 4 Renovation of clinical evaluation and new biomarkers.- 5 Clinical Systems Neuroscience.- PART III RISK FACTORS IN NEURODEGENERATION.- 6 Genetic risk factors for neurodegenerative diseases.- 7 Intermediate phenotypes approach for neuropsychiatric disorders.- PART IV FUTURE DIRECTIONS FOR THERAPY.- 8 Significance of mechanism-oriented research toward neuronal protection therapy against neurodegenerative disorders ~ ZNRF1 E3 ubiquitin ligase as a critical mediator for Wallerian degeneration and neuronal apoptosis.- 9 Drug development for neurodegenerative diseases.- 10 Physical therapy and rehabilitation in patients with degenerative cerebellar diseases: current evidence and future direction.- 11 Home- and Community-based medical care for neurodegenerative diseases -ALS as an illustration-.- PART V HEALTH PROMOTION: PREVENTION AND QUALITY OF LIFE.- 12 Information Environment and Brain Function: A New Concept of the Environment for the Brain.- 13 Social Implementation of Neurodegenerative Disease Research and Neuroethics.-

Keiji Wada, M.D., Ph.D., National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan.