Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes
(Sprache: Englisch)
Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing...
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Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.
Klappentext zu „Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes “
The NATO Advanced Study Institute of "Molecular and Applied Aspects of Oxida tive Drug Metabolizing Enzymes" was held in Tekirova, Antalya, Turkey, from August 31 to September 11, 1997. This Institute was the third of a series of the NATO ASIs on a similar topic relating to the enzymes of oxidative metabolism of xenobiotics. The first NATO ASI in this series, entitled "Molecular Aspects of Monooxygenases and Bioactiva tion of Toxic Compounds" (NATO ASI Series A: Life Sciences, Vol. 202), was held in
Written by leading researchers in the fields of biochemistry, molecular biology, genetics, pharmacology, toxicology, biotechnology and cancer, this is a comprehensive update on molecular biology and biochemistry of cytochromes P450 and flavin containing monoxygenases. The volume provides expert analysis of the genetic polymorphism of these enzymes in the clinic, in drug discovery and development, and discussion of their role in predisposition for, and prevention of chemical carcinogens in humans.
Inhaltsverzeichnis zu „Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes “
The Fate of Xenobiotics in the Body; Enzymes of Metabolism; J.B. Schenkman.Protein-Protein Interactions in the P450 Monooxygenase System; J.B. Schenkman, et al.
Structures of Mitochondrial P450 System Proteins; I. Hanukoglu.
Biochemical Aspects of Flavin-Containing Monooxygenases (FMOs); E. Hodgson, et al.
Expression and Regulation of Flavin-Containing Monooxygenases; R.M. Philpot, et al.
Correlations between in Vivo and in Vitro
Studies in Human Drug Metabolism; M. Eichelbaum.
Pharmacogenetics: Polymorphisms in Xenobiotic Metabolism; F.J. Gonzalez.
Clinical Aspects of Polymorphic Drug Metabolism in Humans; M. Eichelbaum.
Genetic Polymorphisms of Cytochromes P450 1A1 and 2E1 and Glutathione S-Transferase M1 and Cancer Susceptibility in the Human; M. Watanabe.
Cytochrome P450 Isoforms: Insecticide Metabolism in Insects and Mammals and Role in Insecticide Resistance; E. Hodgson, et al.
Inhibitors of CYP51 as Antifungal Agents and Resistance to Azole Antifungals; S.L. Kelly, et al.
The Role of Oxidative Drug Metabolizing Enzymes in Liver and Lung Specific Toxicity; R.M. Philpot.
Importance of Drug Metabolism in Drug Discovery and Development; R. Gasser.
7 additonal articles. Index
Bibliographische Angaben
- 2012, Softcover reprint of the original 1st ed. 1999, VIII, 294 Seiten, Masse: 17,8 x 25,4 cm, Kartoniert (TB), Englisch
- Herausgegeben: Emel Arinç, John B. Schenkman, Ernest Hodgson
- Verlag: Springer, Berlin
- ISBN-10: 146137202X
- ISBN-13: 9781461372028
Sprache:
Englisch
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