Mitochondrial Medicine

Using QSAR Models to Predict Mitochondrial Targeting by Small Molecule Xenobiotics within Living Cells.- DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: An Update.- Synthesis and Characterization of Mitochondria-Targeted Triphenyltriphenylphosphonium Bolaamphiphiles.- Synthesis and Evaluation of 18F-labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging.- Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear beta-Phosphorylated Nitrones: Preparation, 31P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Anti-Apoptotic Properties.- Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as exomarkers of Mitochondrial Hydrogen Peroxide.- Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes.- Imaging Mitochondrial Hydrogen Peroxide in Living Cells.- Synthesis and Testing Of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin.- Bridging the Gap between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria.- Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis.- Mt-fura-2, a ratiometric Mitochondria-targeted Ca2+ sensor. Determination of spectroscopic properties and Ca2+ Imaging Assays.- Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs.- Targeting the Mitochondrial Genome via a MITO-Porter: Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function.- mTRIP, an Imaging Tool to Investigate Mitochondrial DNA dynamics in Physiology and Disease at the Single-Cell Resolution.- Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots.- Norbormide-based Probes and