Metallomics

Preface
 
PART I. Analytical Methods and Strategies in Metallomics
 
THE POSITION OF METALLOMICS WITHIN OTHER OMICS FIELDS
Introduction
Metallome and Metallomics in Relation to Other "-Ome" and "-Omics" Fields
Is Metallomics Feasible as a Global Study of the Metallome
Approaching the Metallome: Study of Metallome Subgroups
Analytical Strategies in Metallomics
Functional Connections Between DNA, Proteins, Metabolites, and Metals
Metallothiolomics as Example for Metallomics Studies of a Metallome Subgroup
Concluding Remarks
 
COUPLING TECHNIQUES AND ORTHOGONAL COMBINATION OF MASS SPECTROMETRIC TECHNIQUES
Introduction
Analytical Techniques for Metallomics
Ionization Principles and Mass Spectrometric Detectors for Speciation
Overview about Coupling Techniques
Finals Remarks and Outlook
 
QUALITY CONTROL IN SPECIATION ANALYSIS USING HPLC WITH ICP-MS AND ESI MS/MS: FOCUS ON QUANTITATION STRATEGIES USING ISOTOPE DILUTION ANALYSIS
Introduction
Synergetic Use of Elemental and Organic Mass Spectrometry in Compound Quantitation and Quality Assurance of Food Selenium Speciation
The Role of Species-Specific Isotopic Dilution in Increasing Metrological Traceability for the Quantification of Bioinorganic Species
 
NOVEL METHODS FOR BIOIMAGING INCLUDING LA-ICP-MS, NanoSIMS, TEM/X-EDS, AND SXRF
Introduction
Bioimaging by LA-ICP-MS
Bioimaging by NanoSIMS
Bioimaging by TEM/X-EDS
Bioimaging by SXRF
Conclusions and Outlook
 
ELECTROCHEMISTRY COUPLED TO MASS SPECTROMETRY FOR INVESTIGATING OXIDATIVE METABOLISM OF PT-BASED DRUG CONJUGATES: A NOVEL APPROACH
Introduction
EC-MS Methodology
EC-MS of Thiols
Influence of Cisplatin on Thiol Oxidation
Conclusions
 
PART II. Metallomics in Environment and Nutrition
 
SELENIUM AND SELENIUM SPECIES
Speciation Analysis Especially of Tin and Selenium in Environmental Matrices
Selenium Species Extraction and Speciation in Plants and Yeast
 
ARSENIC AND AS

Bernhard Michalke is leader of the research group "Elements and Element Speciation" and of the "Central Inorganic Analysis Division" as well as deputy director of the research unit "Analytical BioGeoChemistry" at the Helmholtz Center Munich - German Research Center for Environmental Health.
Since 1996 he has been lecturer at the Institute of Analytical Chemistry and Food Chemistry of the Technical University of Graz, Austria, where he received his habilitation in analytical chemistry in 1999. Since 1988, he is principal researcher at the Helmholtz Center Munich.
His reasearch interests encompass speciation projects related to environmental health, i.e. the exposure and chemical speciation of neuro-degenerative elements such as manganese and species related neuro-toxic effects in the central nervous system. He has published more than 170 peer reviewed articles and 10 book chapters. Since 1998, he has been co-organizer of several international conferences.