Introduction to Pharmaceutical Analytical Chemistry
(Sprache: Englisch)
The definitive textbook on the chemical analysis of pharmaceutical drugs -- fully revised and updated
Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and...
Introduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and...
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Klappentext zu „Introduction to Pharmaceutical Analytical Chemistry “
The definitive textbook on the chemical analysis of pharmaceutical drugs -- fully revised and updatedIntroduction to Pharmaceutical Analytical Chemistry enables students to gain fundamental knowledge of the vital concepts, techniques and applications of the chemical analysis of pharmaceutical ingredients, final pharmaceutical products and drug substances in biological fluids. A unique emphasis on pharmaceutical laboratory practices, such as sample preparation and separation techniques, provides an efficient and practical educational framework for undergraduate studies in areas such as pharmaceutical sciences, analytical chemistry and forensic analysis. Suitable for foundational courses, this essential undergraduate text introduces the common analytical methods used in quantitative and qualitative chemical analysis of pharmaceuticals.
This extensively revised second edition includes a new chapter on chemical analysis of biopharmaceuticals, which includes discussions on identification, purity testing and assay of peptide and protein-based formulations. Also new to this edition are improved colour illustrations and tables, a streamlined chapter structure and text revised for increased clarity and comprehension.
* Introduces the fundamental concepts of pharmaceutical analytical chemistry and statistics
* Presents a systematic investigation of pharmaceutical applications absent from other textbooks on the subject
* Examines various analytical techniques commonly used in pharmaceutical laboratories
* Provides practice problems, up-to-date practical examples and detailed illustrations
* Includes updated content aligned with the current European and United States Pharmacopeia regulations and guidelines
Covering the analytical techniques and concepts necessary for pharmaceutical analytical chemistry, Introduction to Pharmaceutical Analytical Chemistry is ideally suited for students of chemical and pharmaceutical sciences as well as analytical
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chemists transitioning into the field of pharmaceutical analytical chemistry.
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Inhaltsverzeichnis zu „Introduction to Pharmaceutical Analytical Chemistry “
Preface to the Second Edition xvAbbreviations xvii
Symbols and Units xxi
1 Introduction to Pharmaceutical Analytical Chemistry 1
1.1 Introduction 1
1.2 Pharmaceutical Analytical Chemistry 4
1.3 This Textbook 7
2 Marketing Authorizations, Pharmaceutical Manufacturing, and International Pharmacopoeias 9
2.1 Introduction 9
2.2 Marketing Authorization and Industrial Production 10
2.3 Pharmacopoeias 13
2.4 Life Time of Pharmaceutical Preparations and Ingredients 14
3 Fundamentals of Bases, Acids, Solubility, Polarity, Partition, and Stereochemistry 17
3.1 Acids, Bases, pH, and pKa 17
3.2 Buffers 19
3.3 Acid and Base Properties of Drug Substances 20
3.4 Distribution Between Phases 21
3.5 Stereoisomers 26
3.6 Active Pharmaceutical Ingredients - A Few Examples 28
3.7 Stability of Drug Substances 34
4 Fundamentals of Pharmaceutical Analytical Chemistry 37
4.1 Pharmaceutical Analytical Chemistry 37
4.2 How to Specify Quantities, Concentrations, and Compositions of Mixtures 39
4.3 Laboratory Equipment 43
4.4 How to Make Solutions and Dilutions 52
4.5 Errors, Accuracy, and Precision 54
4.6 Statistical Tests 56
4.7 Linear Regression Analysis 65
4.8 How to Present an Analytical Result 68
4.9 Additional Words and Terms 70
5 Titration 73
5.1 Introduction 73
5.2 Potentiometric Titration and Electrodes 79
5.3 Aqueous Acid-Base Titrations 82
5.4 Titration in Non-aqueous Solvents 88
5.5 Redox Titrations 91
5.6 Alternative Principles of Titration 95
6 Introduction to Spectroscopic Methods 97
6.1 Electromagnetic Radiation 97
6.2 Molecules and Absorption of Electromagnetic Radiation 99
6.3 Absorbing Structures - Chromophores
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101
6.4 Fluorescence 101
6.5 Atoms and Electromagnetic Radiation 102
7 UV-Vis Spectrophotometry 105
7.1 Areas of Use 105
7.2 Quantitation 106
7.3 Absorbance Dependence on Measurement Conditions 108
7.4 Identification 110
7.5 Instrumentation 111
7.6 Practical Work and Method Development 115
7.7 Test of Spectrophotometers 116
7.8 Fluorimetry 119
8 IR Spectrophotometry 121
8.1 IR Spectrophotometry 121
8.2 Instrumentation 125
8.3 Recording by Transmission, Diffuse Reflectance, and Attenuated Total Reflection 125
8.4 Instrument Calibration 128
8.5 NIR Spectrophotometry 129
9 Atomic Spectrometry 131
9.1 Applications of Atomic Spectrometry 131
9.2 Atomic Absorption Spectrometry (AAS) 132
9.3 AAS Instrumentation 132
9.4 AAS Practical Work and Method Development 137
9.5 Atomic Emission Spectrometry (AES) 138
9.6 Flame Photometry 139
9.7 Inductively Coupled Plasma Emission Spectrometry 140
9.8 Inductively Coupled Plasma Mass Spectrometry 141
10 Introduction to Chromatography 143
10.1 Introduction 143
10.2 General Principles 144
10.3 Retention 146
10.4 Efficiency 149
10.5 Selectivity 151
10.6 Resolution 152
10.7 Peak Symmetry 154
10.8 The Dynamics of Chromatography 155
11 Separation Principles in Liquid Chromatography 159
11.1 Introduction 159
11.2 Reversed-Phase Chromatography 160
11.3 Ion-Pair Chromatography 168
11.4
6.4 Fluorescence 101
6.5 Atoms and Electromagnetic Radiation 102
7 UV-Vis Spectrophotometry 105
7.1 Areas of Use 105
7.2 Quantitation 106
7.3 Absorbance Dependence on Measurement Conditions 108
7.4 Identification 110
7.5 Instrumentation 111
7.6 Practical Work and Method Development 115
7.7 Test of Spectrophotometers 116
7.8 Fluorimetry 119
8 IR Spectrophotometry 121
8.1 IR Spectrophotometry 121
8.2 Instrumentation 125
8.3 Recording by Transmission, Diffuse Reflectance, and Attenuated Total Reflection 125
8.4 Instrument Calibration 128
8.5 NIR Spectrophotometry 129
9 Atomic Spectrometry 131
9.1 Applications of Atomic Spectrometry 131
9.2 Atomic Absorption Spectrometry (AAS) 132
9.3 AAS Instrumentation 132
9.4 AAS Practical Work and Method Development 137
9.5 Atomic Emission Spectrometry (AES) 138
9.6 Flame Photometry 139
9.7 Inductively Coupled Plasma Emission Spectrometry 140
9.8 Inductively Coupled Plasma Mass Spectrometry 141
10 Introduction to Chromatography 143
10.1 Introduction 143
10.2 General Principles 144
10.3 Retention 146
10.4 Efficiency 149
10.5 Selectivity 151
10.6 Resolution 152
10.7 Peak Symmetry 154
10.8 The Dynamics of Chromatography 155
11 Separation Principles in Liquid Chromatography 159
11.1 Introduction 159
11.2 Reversed-Phase Chromatography 160
11.3 Ion-Pair Chromatography 168
11.4
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Autoren-Porträt von Stig Pedersen-Bjergaard, Bente Gammelgaard, Trine G. Halvorsen
STIG PEDERSEN-BJERGAARD is Professor at the Department of Pharmacy, University of Oslo and Professor at the Department of Pharmacy, University of Copenhagen.BENTE GAMMELGAARD is Professor at the Department of Pharmacy, University of Copenhagen.
TRINE GRØNHAUG HALVORSEN is Associate Professor at the Department of Pharmacy, University of Oslo.
Bibliographische Angaben
- Autoren: Stig Pedersen-Bjergaard , Bente Gammelgaard , Trine G. Halvorsen
- 2019, 2. Aufl., 544 Seiten, Masse: 17 x 24,4 cm, Kartoniert (TB), Englisch
- Verlag: Wiley & Sons
- ISBN-10: 1119362725
- ISBN-13: 9781119362722
- Erscheinungsdatum: 19.04.2019
Sprache:
Englisch
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