Human Interphase Chromosomes
Biomedical Aspects
(Sprache: Englisch)
This book explores the relationship of human interphase chromosomes to health and disease, presenting basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease.
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This book explores the relationship of human interphase chromosomes to health and disease, presenting basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease.
Klappentext zu „Human Interphase Chromosomes “
This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization and inheritance of genetic information within and between species. Current biomedical sciences of post-genomic era refocus basic and applied studies of interphase nuclei genetics and genomics with special attention to interphase chromosome behavior in health and disease. Additionally, related processes are a target of studies elucidating the role of interphase chromosome behavior during development, chromosome/DNA replication, DNA reparation etc. Studies of interphase nuclei have an appreciable impact on different areas of biomedical sciences such as cell biology, neurobiology, cancer research, developmental biology, epigenetics, cytogenetics, and medical genetics, as a whole. Moreover, development of innovative and emergent technologies to analyze interphase nuclei are closely associated with application of these techniques in clinical, diagnostic and research practice to solve reproductive problems (including infertility and spontaneous abortions), to investigate congenital malformations (including those produced by aneuploidy and other chromosome abnormalities); genetic diseases (including cardiac, immune, neurological and psychiatric diseases), and cancer. This title will serve as a source of new valuable information and promising ideas for a wide audience of professionals in biomedicine including researchers, scientists, and healthcare professionals in human genetics, cytogenetics, and developmental biology.
Inhaltsverzeichnis zu „Human Interphase Chromosomes “
Introduction. The view on human interphase chromosomes in postgenomic era.- Interphase chromosome behavior in normal and diseased cells.- Nuclear architecture, chromosome domains and genetic damage.- Interphase chromosome of the human brain: the biological and clinical meaning of neural aneuploidy.- Differentiating chromosome fragmentation and premature chromosome condensation.- Chromosomes and nuclear organization in ICF Syndrome.- Interphase cytogenetics at the earliest stages of human development.- Organization of chromosomes in human sperm nucleus.- Interphase chromosome-specific multicolor banding.- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei.- Technological solutions in human interphase cytogenetics.- Appendix: Molecular cytogenetics and interphase chromosomes on the internet.- Index.
Autoren-Porträt
^400 publications.Svetlana G. Vorsanova (PhD, Dr. Sci, professor) is a head of laboratory of molecular cy^600 publications.
Yuri B. Yurov (PhD, Dr. Sci, professor; 1951-2017) was a pioneer of interphase molecular cytogenetics. He was the founding editor of Molecular Cytogenetics (BMC/Springer/Nature). He has (co-)authored >650 publications, including descriptions of groundbreaking studies in molecular cytogenetics of the human brain.
Bibliographische Angaben
- 2013, XVII, 216 Seiten, Masse: 15,5 x 23,5 cm, Gebunden, Englisch
- Herausgegeben: Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov
- Verlag: Springer, Berlin
- ISBN-10: 1461465575
- ISBN-13: 9781461465577
- Erscheinungsdatum: 03.04.2013
Sprache:
Englisch
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