Homology Modeling
Methods and Protocols
(Sprache: Englisch)
Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary...
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Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.
Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.
Klappentext zu „Homology Modeling “
Knowledge about protein tertiary structure can guide experiments, assist in the understanding of structure-function relationships, and aid the design of new therapeutics for disease. Homology modeling is an in silico method that predicts the tertiary structure of an amino acid sequence based on a homologous experimentally determined structure. In, Homology Modelling: Methods and Protocols experts in the field describe each homology modeling step from first principles, provide case studies for challenging modeling targets and describe methods for the prediction of how other molecules such as drugs can interact with the protein. Written in the highly successful Methods in Molecular Biology(TM) series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.Thorough and intuitive, Homology Modelling: Methods and Protocols guides scientists in the available homology modeling methods.
Inhaltsverzeichnis zu „Homology Modeling “
1. Classification of Proteins: Available Structural Space for MolecularModelling Antonina Andreeva 2. Effective Techniques for Protein Structure MiningStefan J. Suhrer, Markus Gruber, Markus Wiederstein, Manfred J. Sippl
3. Methods for Sequence-structure Alignment ?eslovas Venclovas
4. Force Fields for Homology Modeling Andrew J. Bordner
5. Automated Protein Structure Modeling with SWISS-MODEL Workspace and the Protein Model Portal Lorenza Bordoli & Torsten Schwede
6. A Practical Introduction to Molecular Dynamics Simulations: Applications to Homology Modeling Alessandra Nurisso, Antoine Daina & Ross C. Walker7. Methods for Accurate Homology Modeling by Global OptimizationKeehyoung Joo, Jinwoo Lee, Jooyoung Lee
8. Ligand-Guided Receptor OptimizationVsevolod Katritch, Manuel Rueda and Ruben Abagyan
9. Loop Simulations Maxim Totrov
10. Methods of Protein Structure ComparisonIrina Kufareva and Ruben Abagyan
11. Homology Modeling of Class A G Protein-Coupled Receptors Stefano Costanzi
12. Homology Modeling of Transporter Proteins (Carriers and Ion Channels) Aina Westrheim Ravna and Ingebrigt Sylte
13. Methods for the Homology Modeling of Antibody Variable Regions Aroop Sircar
14. Investigating Protein Variants using Structural Calculation Techniques Jonas Carlsson and Bengt Persson
15. Macromolecular Assembly Structures by Comparative Modeling and Electron Microscopy Keren Lasker, Javier A. Velázquez-Muriel, Benjamin M. Webb, Zheng Yang, Thomas E. Ferrin, and Andrej Sali
16. Preparation and Refinement of Model Protein-Ligand Complexes Andrew J.W. Orry and Ruben Abagyan
17. Modeling Peptide-protein Interactions Nir London, Barak Raveh, Ora Schueler-Furman
18. Comparison of Common Homology Modeling Algorithms: Application of User-defined Alignments Michael A. Dolan, James W. Noah, and Darrell Hurt Keehyoung Joo, Jinwoo Lee, Jooyoung Leein-Coupled Receptors Stefano Costanzi
12.
... mehr
Homology Modeling of Transporter Proteins (Carriers and Ion Channels) Aina Westrheim Ravna and Ingebrigt Sylte
13. Methods for the Homology Modeling of Antibody Variable Regions Aroop Sircar
14. Investigating Protein Variants using Structural Calculation Techniques Jonas Carlsson and Bengt Persson
15. Macromolecular Assembly Structures by Comparative Modeling and Electron Microscopy Keren Lasker, Javier A. Velázquez-Muriel, Benjamin M. Webb, Zheng Yang, Thomas E. Ferrin, and Andrej Sali
16. Preparation and Refinement of Model Protein-Ligand Complexes Andrew J.W. Orry and Ruben Abagyan
17. Modeling Peptide-protein Interactions Nir London, Barak Raveh, Ora Schueler-Furman
18. Comparison of Common Homology Modeling Algorithms: Application of User-defined Alignme
13. Methods for the Homology Modeling of Antibody Variable Regions Aroop Sircar
14. Investigating Protein Variants using Structural Calculation Techniques Jonas Carlsson and Bengt Persson
15. Macromolecular Assembly Structures by Comparative Modeling and Electron Microscopy Keren Lasker, Javier A. Velázquez-Muriel, Benjamin M. Webb, Zheng Yang, Thomas E. Ferrin, and Andrej Sali
16. Preparation and Refinement of Model Protein-Ligand Complexes Andrew J.W. Orry and Ruben Abagyan
17. Modeling Peptide-protein Interactions Nir London, Barak Raveh, Ora Schueler-Furman
18. Comparison of Common Homology Modeling Algorithms: Application of User-defined Alignme
... weniger
Bibliographische Angaben
- 2012, 2012, XI, 419 Seiten, 55 farbige Abbildungen, Masse: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Andrew J. W. Orry, Ruben Abagyan
- Verlag: Springer, Berlin
- ISBN-10: 1617795879
- ISBN-13: 9781617795879
- Erscheinungsdatum: 10.02.2012
Sprache:
Englisch
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