Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane
(Sprache: Englisch)
Framed by a statistical physics perspective, this volume describes both the process of self-assembly and the impact of spatial organization on the function of membrane proteins. Using methods from equilibrium and non-equilibrium statistical mechanics, the...
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Framed by a statistical physics perspective, this volume describes both the process of self-assembly and the impact of spatial organization on the function of membrane proteins. Using methods from equilibrium and non-equilibrium statistical mechanics, the text demonstrates the importance of the protein-protein interactions.
Klappentext zu „Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane “
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.
Inhaltsverzeichnis zu „Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane “
Introduction.- The Role of Fragmentation on the Formation of Homomeric Protein Complexes.- Collective Response of Self-organised Clusters of Mechanosensitive Channels.- Assembly and Fragmentation of Tat Pores.- Conclusion.
Bibliographische Angaben
- Autor: Ksenia Guseva
- 2011, XII, 80 Seiten, mit Abbildungen, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3642239870
- ISBN-13: 9783642239878
- Erscheinungsdatum: 02.10.2011
Sprache:
Englisch
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