Fatigue

Looking Back.- The Scientific Contributions of Brenda Bigland-Ritchie.- Section I: Fatigue of Single Muscle Fibers.- 1. Myofibrillar Fatigue versus Failure of Activation.- 2. Mechanisms of Excitation-Contraction Coupling Relevant to Skeletal Muscle Fatigue.- 3. The Role of Intracellular Acidosis in Muscle Fatigue.- 4. Role of Interstitial Potassium.- Section II: Fatigue at the Neuromuscular Junction.- 5. Fatigue at the Neuromuscular Junction: Branch Point vs. Presynaptic vs. Postsynaptic Mechanisms.- 6. The Role of the Sarcolemma Action Potential in Fatigue.- 7. Single Fiber Electromyography in Studies of Neuromuscular Function.- Section III: Fatigue of Single Motor Units.- 8. Intrinsic Properties of Motoneurons: Implications for Muscle Fatigue.- 9. Neuromuscular Frequency Coding and Fatigue.- 10. Human Motor Units Studied by Spike-Triggered Averaging and Intraneural Motor Axon Stimulation.- 11. Human Motor Units Studied by Intramuscular Microstimulation.- Section IV: Fatigue Studied with NMR Techniques.- 12. Bioenergetics and Muscle Cell Types.- 13. Metabolic Correlates of Fatigue from Different Types of Exercise in Man.- 14. Mechanisms of Human Muscle Fatigue: Quantitating the Contribution of Metabolic Factors and Activation Impairment.- 15. Emerging Opportunities with NMR.- Section V: The Case for Segmental Motor Mechanisms.- 16. Variable-Frequency Stimulation Patterns for the Optimization of Force during Muscle Fatigue: Muscle Wisdom and the Catch-like Property.- 17. Overview: Potential Role of Segmental Motor Circuitry in Muscle Fatigue.- 18. The Fusimotor System: Its Role in Fatigue.- 19. Role of Muscle Afferents in the Inhibition of Motoneurons during Fatigue.- Section VI: The Case for Central Fatigue.- 20. Central Fatigue: Critical Issues, Quantification and Practical Implications.- 21. Single-Trial Readiness Potentials and Fatigue.- 22. The Senses of Effort and Force during Fatiguing Contractions.- 23. Tryptophan, 5-Hydroxytryptamine and a Possible