Erythropoietins, Erythropoietic Factors, and Erythropoiesis
Molecular, Cellular, Preclinical, and Clinical Biology
(Sprache: Englisch)
Of interest to researchers and clinical investigators in academia and biotechnology, this updated second edition is a one-stop guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors.
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Of interest to researchers and clinical investigators in academia and biotechnology, this updated second edition is a one-stop guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors.
Klappentext zu „Erythropoietins, Erythropoietic Factors, and Erythropoiesis “
A comprehensive one-source guide to the most current information on red blood cell formation and the action of recombinant human erythropoietins. Topics covered include: erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed. The text is ideal for researchers and clinical investigators in academia, biotechnology, and pharmaceutical companies, as well as clinical research associates, clinical monitors, and physician investigators.
This second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed.
This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.
This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.
Inhaltsverzeichnis zu „Erythropoietins, Erythropoietic Factors, and Erythropoiesis “
Background.- Erythropoiesis: an overview.- Regulation of endogenous erythropoietin production.- Biology of erythropoietin.- Erythropoiesis-genetic abnormalities.- Erythropoiesis-stimulating agents.- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin.- Commercial production of recombinant erythropoietins.- Biosimilar epoetins.- New molecules and formulations.- Erythropoietin receptor.- Structural basis for the signal transduction of erythropoietin.- Intracellular signaling by the erythropoietin receptor.- Mechanism of erythropoietin receptor activation.- Clinical utility.- Pharmacokinetics of erythropoiesis-stimulating agents.- Use of erythropoietic stimulating agents in the setting of renal disease.- Abuse of recombinant erythropoietins and blood products by athletes.- Role and regulation of iron metabolism in erythropoiesis and disease.- Nonhematopoietic effects of erythropoiesis-stimulating agents.
Bibliographische Angaben
- 2nd revised and extended edition, 330 Seiten, 11 farbige Abbildungen, 45 Schwarz-Weiss-Abbildungen, Masse: 17,2 x 23,9 cm, Gebunden, Englisch
- Herausgegeben: Steven G. Elliott, MaryAnn Foote, Graham Molineux
- Verlag: Springer
- ISBN-10: 3764386940
- ISBN-13: 9783764386948
- Erscheinungsdatum: 15.04.2009
Sprache:
Englisch
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