Developmental Toxicology

Volume Overview - Introduction.-In Vivo Models of Developmental Toxicology.-Caenorhabditis Elegans as a Model in Developmental Toxicology.-Zebrafish Embryo Developmental Toxicology Assay.-Gene Knockdown by Morpholino-modified Oligonucleotides in the Zebrafish (Danio rerio) Model: Applications for Developmental Toxicology.-An Amphibian Model for Studies of Developmental Reproductive Toxicity.-Avian Models in Teratology and Developmental Toxicology.-Overview of In Vitro Models in Developmental Toxicology.-Primary Cell and Micromass Culture in Assessing Developmental Toxicity.-Embryonic Stem Cell Test (EST): Stem cell Use in Predicting Developmental Cardiotoxicity and Osteotoxicity.-Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) Assay.-The Murine Limb Bud in Culture as an In Vitro Teratogenicity Test System.-Rodent Whole Embryo Culture.-Rabbit Whole Embryo Culture.-Assessment of Xenobiotic Biotransformation Including Reactive Oxygen Species Generation in the Embryo using Benzene as an Example.-Methodological Approaches to Cytochrome P450 Profiling in Embryos.-Analysis of Nrf2-Mediated Transcriptional Induction of Antioxidant Response in Early Embryos.-Regulation and Control of AP-1 Binding Activity in Embryotoxicity.-Thioredoxin Redox Status Assessment During Embryonic Development: The Redox Western.-Methods for the Determination of Plasma or Tissue Glutathione Levels.-Oxidative Stress, Thiols, and Redox Profiles.-A Review of Toxicogenomic Approaches in Developmental Toxicology.-Epigenetic Approaches and Methods in Developmental Toxicology: Role of HDAC Inhibition in Teratogenic Events.-DNA Methylation Screening and Analysis.-Assessment of Histiotrophic Nutrition using Fluorescent Probes.-Diabetic Embryopathy.-Gene Expression Analysis in Developing Embryos: In situ Hybridization.-Assessment of Gross Fetal Malformations: The Modernized Wilson Technique and Skeletal Staining.