Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity

Section I: Transferases and Hydrolases Involved in Phase II Conjugation-Deconjugation Reactions, Genetic Polymorphism and Regulation of Expression.- 1 The Uridine Diphosphate Glueuronosyltransferase Multigene Family: Function and Regulation With 7 Figures.- 2 Sulfotransferase Enzymes With 6 Figures.- 3 Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Induction of the Ya Subunit Gene With 6 Figures.- 4 Human N-Acetyltransferases With 3 Figures.- 5 Genetic Regulation of the Subcellular Localization and Expression of Glucuronidase With 5 Figures.- 6 Microsomal Amidases and Carboxylesterases With 5 Figures.- 7 O-, N, and S-Methyltransferases With 2 Figures.- Section II: Regulation of Phase II Conjugation: Deconjugation Reactions in Intact Cells and Tissues.- 8 Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactions With 5 Figures.- 9 Regulation of Drug Conjugate Production by Futile Cycling in Intact Cells With 4 Figures.- 10 Pharmacokinetic Modeling of Drug Conjugates With 22 Figures.- 11 Regulation of Drug Conjugate Processing by Hepatocellular Transport Systems With 1 Figure.- Section III: Pharmacology and Toxicology of Drug Conjugates.- 12 Biologically Active Conjugates of Drugs and Toxic Chemicals With 5 Figures.- 13 Acyl Glucuronides as Chemically Reactive Intermediates With 10 Figures.- 14 Roles of Uridine Diphosphate Glucuronosyltransferases in Chemical Carcinogenesis With 9 Figures.- 15 Sulfonation in Chemical Carcinogenesis With 11 Figures.- 16 Glutathione Conjugate-Mediated Toxicities With 8 Figures.- 17 Challenges and Directions for Future Research.