Chronic Hepatitis C Virus
Advances in Treatment, Promise for the Future
(Sprache: Englisch)
Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this...
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Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.
Klappentext zu „Chronic Hepatitis C Virus “
Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future is a valuable resource
... mehr
for all physicians caring for patients with chronic HCV.
... weniger
Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.atment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chroni
Inhaltsverzeichnis zu „Chronic Hepatitis C Virus “
Section I: Natural History of Chronic HCVCh. 1- Epidemiology of Chronic HCV
Gary Davis
Ch. 2- Acute HCV
Katja Deterding
Heiner Wedemeyer
Michael P. Manns
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
Xavier Forns
Ch. 4- Chronic HCV and Steatosis
Dawn McDowell Torres
Stephen A. Harrison
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
Morris Sherman
Ch. 6- Extrahepatic Manifestations of Chronic HCV
Antonio Craxi
Vincenza Calvaruso
Ch. 7- Chronic HCV and HIV Co-infection
Patrick Ingiliz
Maud Lemoine
Yves Benhamou
Ch. 8- Chronic HCV in Patients with Renal Disease
Paul Martin
Fabrizio Fabrizi
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
Bruce Bacon
Fasiha Kanwal
Section II: Treatment of Chronic HCV with Interferon Based Therapy
Ch. 10- Treatment with Interferon and Ribavirin
Stuart Roberts
William Kemp
Ch. 11- Immune Modulators and Other Agents
Edgar D. Charles
Ira M. Jacobson
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
Jean-Michel Pawlotsky
Ch. 13- Response Guided Therapy
Mitchell Shiffman
Ch. 14- Managing the Side Effects of Therapy
Curtis Cooper
Ch. 15- The Genetics of Virologic Response
Andrew J Muir
Alison B. Jazwinski
Ch. 16- Maintenance Therapy with Peginterferon
Nezem Afdahl
Raza Malik
Section III: Anti-viral Therapy for Chronic HCV
... mehr
Ch. 17- Anti-viral Targets in HCV
Bernd Kronenberger
Stefan Zeuzem
Ch. 18- Mutations and the Development of Anti-viral Resistance
Geoffrey Dusheiko
Anna Maria Geretti
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
Patrick Marcellin
Nathalie Boyer
Tarik Asselah
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
Ed Gane
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
Donald M. Jensen
Andrew Aronsohn
Section IV: Liver Transplantation for Chronic HCV
Ch. 22- Natural History of Chronic HCV after Liver Transplantation
Michael Charlton
Bart J. Veldt
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
Robert Brown
Elizabeth C. Verna
Ch. 24- Treating HCV Prior to Liver Transplantation
Greg Everson
Alvaro Martinez-Camacho
Brett E. Fortune
Ch. 25- Treating HCV after Liver Transplantation
Sammy Saab
Michael Chang
Hubert Sung
Ch. 2- Acute HCV
Katja Deterding
Heiner Wedemeyer
Michael P. Manns
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
Xavier Forns
Ch. 4- Chronic HCV and Steatosis
Dawn McDowell Torres
Stephen A. Harrison
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
Morris Sherman
Ch. 6- Extrahepatic Manifestations of Chronic HCV
Antonio Craxi
Vincenza Calvaruso
Ch. 7- Chronic HCV and HIV Co-infection
Patrick Ingiliz
Maud Lemoine
Yves Benhamou
Ch. 8- Chronic HCV in Patients with Renal Disease
Paul Martin
Fabrizio Fabrizi
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
Bruce Bacon
Fasiha Kanwal
Section II: Treatment of Chronic HCV with Interferon Based Therapy
Ch. 10- Treatment with Interferon and Ribavirin
Stuart Roberts
William Kemp
Ch. 11- Immune Modulators and Other Agents
Edgar D. Charles
Ira M. Jacobson
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
Jean-Michel Pawlotsky
Ch. 13- Response Guided Therapy
Mitchell Shiffman
Ch. 14- Managing the Side Effects of Therapy
Curtis Cooper
Ch. 15- The Genetics of Virologic Response
Andrew J Muir
Alison B. Jazwinski
Ch. 16- Maintenance Therapy with Peginterferon
Nezem Afdahl
Raza Malik
Section III: Anti-viral Therapy for Chronic HCV
Ch. 17- Anti-viral Targets in HCV
Bernd Kronenberger
Stefan Zeuzem
Ch. 18- Mutations and the Development of Anti-viral Resistance
Geoffrey Dusheiko
Anna Maria Geretti
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
Patrick Marcellin
Nathalie Boyer
Tarik Asselah
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
Ed Gane
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
Donald M. Jensen
Andrew Aronsohn
Section IV: Liver Transplantation for Chronic HCV
Ch. 22- Natural History of Chronic HCV after Liver Transplantation
Michael Charlton
Bart J. Veldt
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
Robert Brown
Elizabeth C. Verna
Ch. 24- Treating HCV Prior to Liver Transplantation
Greg Everson
Alvaro Martinez-Camacho
Brett E. Fortune
Ch. 25- Treating HCV after Liver Transplantation
Sammy Saab
Michael Chang
Hubert Sung
Ch. 2- Acute HCV
Katja Deterding
Heiner Wedemeyer
Michael P. Manns
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
Xavier Forns
Ch. 4- Chronic HCV and Steatosis
Dawn McDowell Torres
Stephen A. Harrison
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
Morris Sherman
Ch. 6- Extrahepatic Manifestations of Chronic HCV
Antonio Craxi
Vincenza Calvaruso
Ch. 7- Chronic HCV and HIV Co-infection
Patrick Ingiliz
Maud Lemoine
Yves Benhamou
Ch. 8- Chronic HCV in Patients with Renal Disease
Paul Martin
Fabrizio Fabrizi
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
Bruce Bacon
Fasiha Kanwal
Section II: Treatment of Chronic HCV with Interferon Based Therapy
Ch. 10- Treatment with Interferon and Ribavirin
Stuart Roberts
William Kemp
Ch. 11- Immune Modulators and Other Agents
Edgar D. Charles
Ira M. Jacobson
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
Jean-Michel Pawlotsky
Ch. 13- Response Guided Therapy
Mitchell Shiffman
Ch. 14- Managing the Side Effects of Therapy
Curtis Cooper
Ch. 15- The Genetics of Virologic Response
Andrew J Muir
Alison B. Jazwinski
Ch. 16- Maintenance Therapy with Peginterferon
Nezem Afdahl
Raza Malik
Section III: Anti-viral Therapy for Chronic HCV
Ch. 17- Anti-viral Targets in HCV
Bernd Kronenberger
Stefan Zeuzem
Ch. 18- Mutations and the Development of Anti-viral Resistance
Geoffrey Dusheiko
Anna Maria Geretti
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
Patrick Marcellin
Nathalie Boyer
Tarik Asselah
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
Ed Gane
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
Donald M. Jensen
Andrew Aronsohn
Section IV: Liver Transplantation for Chronic HCV
Ch. 22- Natural History of Chronic HCV after Liver Transplantation
Michael Charlton
Bart J. Veldt
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
Robert Brown
Elizabeth C. Verna
Ch. 24- Treating HCV Prior to Liver Transplantation
Greg Everson
Alvaro Martinez-Camacho
Brett E. Fortune
Ch. 25- Treating HCV after Liver Transplantation
Sammy Saab
Michael Chang
Hubert Sung
Ch. 17- Anti-viral Targets in HCV
Bernd Kronenberger
Stefan Zeuzem
Ch. 18- Mutations and the Development of Anti-viral Resistance
Geoffrey Dusheiko
Anna Maria Geretti
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
Patrick Marcellin
Nathalie Boyer
Tarik Asselah
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
Ed Gane
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
Donald M. Jensen
Andrew Aronsohn
Section IV: Liver Transplantation for Chronic HCV
Ch. 22- Natural History of Chronic HCV after Liver Transplantation
Michael Charlton
Bart J. Veldt
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
Robert Brown
Elizabeth C. Verna
Ch. 24- Treating HCV Prior to Liver Transplantation
Greg Everson
Alvaro Martinez-Camacho
Brett E. Fortune
Ch. 25- Treating HCV after Liver Transplantation
Sammy Saab
Michael Chang
Hubert Sung
Ch. 2- Acute HCV
Katja Deterding
Heiner Wedemeyer
Michael P. Manns
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
Xavier Forns
Ch. 4- Chronic HCV and Steatosis
Dawn McDowell Torres
Stephen A. Harrison
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
Morris Sherman
Ch. 6- Extrahepatic Manifestations of Chronic HCV
Antonio Craxi
Vincenza Calvaruso
Ch. 7- Chronic HCV and HIV Co-infection
Patrick Ingiliz
Maud Lemoine
Yves Benhamou
Ch. 8- Chronic HCV in Patients with Renal Disease
Paul Martin
Fabrizio Fabrizi
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
Bruce Bacon
Fasiha Kanwal
Section II: Treatment of Chronic HCV with Interferon Based Therapy
Ch. 10- Treatment with Interferon and Ribavirin
Stuart Roberts
William Kemp
Ch. 11- Immune Modulators and Other Agents
Edgar D. Charles
Ira M. Jacobson
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
Jean-Michel Pawlotsky
Ch. 13- Response Guided Therapy
Mitchell Shiffman
Ch. 14- Managing the Side Effects of Therapy
Curtis Cooper
Ch. 15- The Genetics of Virologic Response
Andrew J Muir
Alison B. Jazwinski
Ch. 16- Maintenance Therapy with Peginterferon
Nezem Afdahl
Raza Malik
Section III: Anti-viral Therapy for Chronic HCV
Ch. 17- Anti-viral Targets in HCV
Bernd Kronenberger
Stefan Zeuzem
Ch. 18- Mutations and the Development of Anti-viral Resistance
Geoffrey Dusheiko
Anna Maria Geretti
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
Patrick Marcellin
Nathalie Boyer
Tarik Asselah
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
Ed Gane
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
Donald M. Jensen
Andrew Aronsohn
Section IV: Liver Transplantation for Chronic HCV
Ch. 22- Natural History of Chronic HCV after Liver Transplantation
Michael Charlton
Bart J. Veldt
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
Robert Brown
Elizabeth C. Verna
Ch. 24- Treating HCV Prior to Liver Transplantation
Greg Everson
Alvaro Martinez-Camacho
Brett E. Fortune
Ch. 25- Treating HCV after Liver Transplantation
Sammy Saab
Michael Chang
Hubert Sung
Ch. 2- Acute HCV
Katja Deterding
Heiner Wedemeyer
Michael P. Manns
Ch. 3- Assessing the Progression of Chronic HCV to Cirrhosis
Xavier Forns
Ch. 4- Chronic HCV and Steatosis
Dawn McDowell Torres
Stephen A. Harrison
Ch. 5- Chronic HCV and Hepatocellular Carcinoma
Morris Sherman
Ch. 6- Extrahepatic Manifestations of Chronic HCV
Antonio Craxi
Vincenza Calvaruso
Ch. 7- Chronic HCV and HIV Co-infection
Patrick Ingiliz
Maud Lemoine
Yves Benhamou
Ch. 8- Chronic HCV in Patients with Renal Disease
Paul Martin
Fabrizio Fabrizi
Ch. 9- Does Treatment Alter the Natural History of Chronic HCV
Bruce Bacon
Fasiha Kanwal
Section II: Treatment of Chronic HCV with Interferon Based Therapy
Ch. 10- Treatment with Interferon and Ribavirin
Stuart Roberts
William Kemp
Ch. 11- Immune Modulators and Other Agents
Edgar D. Charles
Ira M. Jacobson
Ch. 12- Measuring HCV RNA and Assessing Virologic Response
Jean-Michel Pawlotsky
Ch. 13- Response Guided Therapy
Mitchell Shiffman
Ch. 14- Managing the Side Effects of Therapy
Curtis Cooper
Ch. 15- The Genetics of Virologic Response
Andrew J Muir
Alison B. Jazwinski
Ch. 16- Maintenance Therapy with Peginterferon
Nezem Afdahl
Raza Malik
Section III: Anti-viral Therapy for Chronic HCV
Ch. 17- Anti-viral Targets in HCV
Bernd Kronenberger
Stefan Zeuzem
Ch. 18- Mutations and the Development of Anti-viral Resistance
Geoffrey Dusheiko
Anna Maria Geretti
Ch. 19- Peginterferon, Ribavirin and Anti-viral Triple Therapy
Patrick Marcellin
Nathalie Boyer
Tarik Asselah
Ch. 20- Treating Chronic HCV without Interferon and/or Ribavirin
Ed Gane
Ch. 21- Maintenance Therapy with Oral Anti-viral Agents
Donald M. Jensen
Andrew Aronsohn
Section IV: Liver Transplantation for Chronic HCV
Ch. 22- Natural History of Chronic HCV after Liver Transplantation
Michael Charlton
Bart J. Veldt
Ch. 23- Use of HCV Positive Organs in Patients with and without Chronic HCV
Robert Brown
Elizabeth C. Verna
Ch. 24- Treating HCV Prior to Liver Transplantation
Greg Everson
Alvaro Martinez-Camacho
Brett E. Fortune
Ch. 25- Treating HCV after Liver Transplantation
Sammy Saab
Michael Chang
Hubert Sung
... weniger
Autoren-Porträt
Mitchell L. Shiffman, MDLiver Institute of Virginia, Bon Secours Health System, Richmond, VA, USA
Bibliographische Angaben
- 2012, XVI, 332 Seiten, 33 farbige Abbildungen, Masse: 18,3 x 26 cm, Gebunden, Englisch
- Herausgegeben: Mitchell L. Shiffman
- Verlag: Springer, Berlin
- ISBN-10: 1461411912
- ISBN-13: 9781461411918
- Erscheinungsdatum: 30.11.2011
Sprache:
Englisch
Rezension zu „Chronic Hepatitis C Virus “
From the reviews:"This book is an important contribution to the field. ... This well-written, concise, and current book will find a home on the shelves of many hepatologists and gastroenterologists. In addition, because it is so readable, it should be useful for students, GI/hepatology fellows, and midlevel providers dealing with patients and doing research. ... This is a concise, updated, and well-written book that belongs in the libraries of healthcare providers and researchers in the field of HCV infection as well as medical institutions." (Paul Angulo, Doody's Review Service, November, 2012)
"Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future represents a timely new text that is focused on the natural history, treatment, and liver transplantation for chronic hepatitis C virus (HCV) infection. ... an excellent background reference for MD and PhD students, trainees, and clinicians in understanding the scientific basis for current management of chronic HCV infection and highlighting key areas for future investigation. ... is a welcome addition to any library and true to its name ... ." (Richard Sterling and Joseph Lim, Gastroenterology, Vol. 143 (6), 2012)
Pressezitat
From the reviews:"This book is an important contribution to the field. ... This well-written, concise, and current book will find a home on the shelves of many hepatologists and gastroenterologists. In addition, because it is so readable, it should be useful for students, GI/hepatology fellows, and midlevel providers dealing with patients and doing research. ... This is a concise, updated, and well-written book that belongs in the libraries of healthcare providers and researchers in the field of HCV infection as well as medical institutions." (Paul Angulo, Doody's Review Service, November, 2012)
"Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future represents a timely new text that is focused on the natural history, treatment, and liver transplantation for chronic hepatitis C virus (HCV) infection. ... an excellent background reference for MD and PhD students, trainees, and clinicians in understanding the scientific basis for current management of chronic HCV infection and highlighting key areas for future investigation. ... is a welcome addition to any library and true to its name ... ." (Richard Sterling and Joseph Lim, Gastroenterology, Vol. 143 (6), 2012)
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