Chromosomal Translocations and Genome Rearrangements in Cancer
(Sprache: Englisch)
This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome...
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This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.
The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics.
Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.
Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics.
Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.
Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
Klappentext zu „Chromosomal Translocations and Genome Rearrangements in Cancer “
This volume collates world experts' insights into the molecular biology of cancer chromosomes, their abnormalities and the subsequent cellular consequences. Exploring themes involving oncogenes, such as by chromosomal translocations, other genome rearrangements and somatic mutations, this book is a review of the field of cancer genetics that presages a new era, as whole genome sequencing becomes more accessible.The work begins with a look at historical themes, such as the analysis of metaphase chromosomes using microscopy and staining techniques, advances in which provided our first broad glimpse into the genetic anatomy of a malignant cell. Readers will learn about the application of DNA molecular cloning techniques in the 1980s, that led to the identification of the genes involved in the Philadelphia and Burkitt's lymphoma chromosomal translocations, solidifying the role of oncogenes and tumour suppressor genes in cancer aetiology via chromosomal alterations and which launched a field in cancer genetics.
Subsequent chapters bring the reader up to date by reviewing recent developments in the field, with dedicated sections on leukaemia/lymphoma, sarcomas and epithelial tumours.
Contributions feature numerous colour tables and illustrations and this volume will provide a basis for understanding cancer chromosomes for many years to come.
Inhaltsverzeichnis zu „Chromosomal Translocations and Genome Rearrangements in Cancer “
Part I Introduction Chapter 1 - A short history of chromosome rearrangements and gene fusions in cancer
Felix Mitelman
Part II General
Chapter 2 Molecular genetics methods in discovery of chromosome structure
Donna Albertson
Chapter 3 Mechanism of recurrent chromosomal translocations
Fred Alt, Richard Frock, Jiazhi Hu
Chapter 4 Chromosome translocations, cancer initiation and clonal evolution
Mel Greaves, Anthony M Ford
Chapter 5 Chromosomal fragile sites and cancer
Michelle LeBeau, Yanwen Jiang, Isabelle Lucas
Chapter 6 Copy number changes in carcinomas: applications
Pamela Rabbitts, Henry Wood
Part III LEUKAEMIA/LYMPHOMA
Chapter 7 Chronic myeloid leukaemia
Junia Melo, Debora A Casolari
Chapter 8 Immunoglobulin and MYC rearrangements in multiple myeloma pathogenesis
P. Leif Bergsagel, W.Michael Kuehl
Chapter 9 Genetic alterations in B cell lymphoma
Riccardo Dalla Favera, Marco Fangazio, Laura Pasqualucci
Chapter 10 Chromosomal translocations and gene rearrangements in acute lymphoblastic leukaemia
Tom Look, Marc Mansour
Chapter 11 Cellular and molecular basis of MLL leukaemias: from transformation mechanisms to novel therapeutic strategies
Chi Wai Eric So, Bernd Zeisig
Chapter 12 Acute promyelocytic leukaemia: from a specific translocation to cure by targeted therapies
Hugues de The, Kim Rice
Chapter 13 Chromosome Abnormalities in AML and their clinical importance
Clara Bloomfield, Krzysztof Mrozek
PART IV SARCOMAS
Chapter 14 Fusion Oncogenes of Sarcomas
Pierre Aman
Chapter 15 Translocations in Ewing Sarcoma
Stephen L Lessnick, Jason M Tanner
PART V EPITHELIAL TUMOURS
Chapter16 RET and thyroid carcinomas
Giancarlo Vecchio, Maria Domenica Castellone
Chapter 17 Gene
... mehr
fusions in prostate cancer
Scott Tomlins, A.S.McDaniel
Chapter 18 Chromosomal Translocations in Lung Cancer
Hiroyuki Mano
Chapter 19 Colon & Ovarian translocations
Paul T. Spellman
PART VI OTHER ASPECTS
Chapter 20 Pre-clinical modeling of chromosomal translocations and inversions
Terry Rabbitts, Katia Ruggero
Chapter 21 Protein complex hierarchy & translocation gene products
Jacqueline Matthews
Chapter 22 Aberrant transcriptional programming in blood cancers
Constanze Bonifer, Peter N. Cockerill, Anetta Ptasinska
Index
Scott Tomlins, A.S.McDaniel
Chapter 18 Chromosomal Translocations in Lung Cancer
Hiroyuki Mano
Chapter 19 Colon & Ovarian translocations
Paul T. Spellman
PART VI OTHER ASPECTS
Chapter 20 Pre-clinical modeling of chromosomal translocations and inversions
Terry Rabbitts, Katia Ruggero
Chapter 21 Protein complex hierarchy & translocation gene products
Jacqueline Matthews
Chapter 22 Aberrant transcriptional programming in blood cancers
Constanze Bonifer, Peter N. Cockerill, Anetta Ptasinska
Index
... weniger
Bibliographische Angaben
- 2016, 1st ed. 2015, IX, 490 Seiten, 69 farbige Abbildungen, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Herausgegeben: Janet D. Rowley, Michelle M. Le Beau, Terence H. Rabbitts
- Verlag: Springer, Berlin
- ISBN-10: 331919982X
- ISBN-13: 9783319199825
- Erscheinungsdatum: 20.10.2015
Sprache:
Englisch
Pressezitat
"An updated review of chromosomal aberrations related to cancer. ... For geneticists and oncologists." (Pediatric Endocrinology Reviews, Vol. 13 (4), June, 2016)
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