Biomarkers in Circulation
Principles
(Sprache: Englisch)
This work presents the details of cancer biomarkers deployed for noninvasive diagnosis in 18 separate body fluids, as well as assessing their potential in the field of personalized cancer therapeutics and the prospects for coordinated regulatory validation.
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This work presents the details of cancer biomarkers deployed for noninvasive diagnosis in 18 separate body fluids, as well as assessing their potential in the field of personalized cancer therapeutics and the prospects for coordinated regulatory validation.
Klappentext zu „Biomarkers in Circulation “
The molecular and genetic signatures of cancer are represented in the peripheral circulation and other body fluids, giving rise to the "liquid biopsy" concept. This new paradigm of molecular profiling of cancer cells offers several advantages over traditional tissue biopsy. It is convenient, noninvasive, conforms to current clinical practice, enables real time disease monitoring and the study of tumor evolution, can easily be sampled multiple times, and this sample is more representative of the heterogeneous cancer cells than biopsy sampling. Indeed, all aspects of cancer molecular genetic information, stemming from DNA (both nuclear and mitochondria), RNA (coding and noncoding), peptides and proteins, metabolites and lipids are present in body fluids as free, cell surface bound or enclosed in membrane vesicles, and are being harnessed for disease management. Additionally, circulating tumor, and tumor stem cells provide prognostic information, and also enable the study of the intricate molecular processes associated with metastasis and drug resistance. This treatise deals with the general principles of the molecular pathology of cancer, and its associated imprints in circulation. The transitional process from discovery, prototype development, translational research, to product development can be complex and costly. The critical path to biomarker development and qualification for successful use in drug development is detailed herein as well.This book is of interest to Cancer Researchers, Oncologists, Clinicians, Surgeons, Medical Students, Nurses, Diagnostic Laboratories, and Pharmaceutical Industries.
Inhaltsverzeichnis zu „Biomarkers in Circulation “
PART ONE: SYNOPSIS OF CANCER BIOMARKERSChapter 1: An Overview of Cancer Biomarkers
Chapter 2: Bodily Fluids and Cancer Biomarkers
PART TWO: CANCER BIOMARKERS IN CIRCULATION
Chapter 3: Circulating Nonspecific Cancer Nucleic Acids
Chapter 4: Circulating Cancer Epigenome
Chapter 5: Circulating Cancer Genome
Chapter 6: Circulating Cancer Transcriptome
Chapter 7: Circulating Cancer Noncoding Transcriptome
Chapter 8: Circulating Cancer Peptidome/Proteome
Chapter 9: Circulating Cancer Metabolome
Chapter 10: Circulating Cancer Mitochondrial Genome
Chapter 11: Circulating Cancer Cells and Tumor Stem Cells
PART THREE: CANCER BIOMARKERS IN TISSUE-SPECIFIC BODY FLUIDS
Chapter 12: Skin Cancer Biomarkers in Exfoliated Skin Cells
Chapter 13: Head and Neck Cancer Biomarkers in Saliva and Oral Rinses
Chapter 14: Lung Cancer Biomarkers in Sputum, Bronchoalveolar Lavage, and Exhaled Breath
Chapter 15: Breast Cancer Biomarkers in Nipple Aspirate Fluid, Ductal Lavage, and Fine Needle Aspirates
Chapter 16: Gastric Cancer Biomarkers in Gastric Fluid
Chapter 17: Hepatobiliary Cancer Biomarkers in Bile
Chapter 18: Pancreatic Cancer Biomarkers in Pancreatic Juice
Chapter 19: Colorectal Cancer Biomarkers in Stool
Chapter 20: Renal Cancer Biomarkers in Urine
Chapter 21: Urinary Bladder Cancer Biomarkers in Urine
Chapter 22: Prostate Cancer Biomarkers in Urine and Expressed Prostatic Secretions
Chapter 23: Testicular Cancer Biomarkers in Semen
Chapter 24: Ovarian Cancer Biomarkers in Blood and Ovarian epithelial brushes/washes
Chapter 25: Endometrial Cancer Biomarkers in Menstrual Flow
Chapter 26: Endometriosis Biomarkers in Menstrual Flow
Chapter 27: Cervical, Vaginal and Vulval Cancer Biomarkers in Secretions or Swaps of Anatomic Sites
Chapter 28: Biomarkers of Hematologic Malignancies in Circulating Leukocytes and Bone Marrow Aspirates
Chapter 29: Nervous System Cancer Biomarkers in Cerebrospinal Fluid
Autoren-Porträt von Gabriel D Dakubo
Dr. Gabriel D. Dakubo is an Assistant Professor of Molecular Medicine and Human Anatomy in the Division of Medical Sciences at the Northern Ontario School of Medicine. He received his BSc and MBChB degrees from the University of Ghana, followed by the pursuance of a Postdoctoral research fellowship in Molecular Medicine at the Ottawa Hospital Research Institute, Canada. Dr. Dakubo's passion is in noninvasive deployment of biomarkers for cancer management. While an expert in mitochondrial genetic alterations in cancer, he also has a keen interest in the inter-genomic communications that occur in the cancer cell, as well as the Slaughter's concept of field cancerization. Dr. Dakubo is well published, and has reviewed for a number of esteemed journals, including Clinical Cancer Research.
Bibliographische Angaben
- Autor: Gabriel D Dakubo
- 2016, 1st ed. 2016, XVI, 299 Seiten, 44 farbige Abbildungen, Masse: 16 x 24,1 cm, Gebunden, Englisch
- Verlag: Springer, Berlin
- ISBN-10: 3319015796
- ISBN-13: 9783319015798
- Erscheinungsdatum: 10.09.2016
Sprache:
Englisch
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