BetaSys

Preface.
- Systems Biology of the Beta-cell - Revisited.
- Established facts and open questions of regulated exocytosis in ?-cells - a background for a focused systems analysis approach.
- Mitochondria and metabolic signals in ?-cells.
- Beta cell ontogenesis and the insulin production apparatus.
- The Mathematical Microscope Making the inaccessible accessible.
- Megnetic Resonance Imaging of Pancreatic Beta Cells.
- Mapping The ?-Cell In 3D At The Nanoscale Using Novel Cellular Electron Tomography And Computational Approaches.
- In vivo Applications of Inorganic Nanoparticles.
- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality.
- The role of the cytoskeleton in transport and release of insulin-containing granules by pancreatic beta-cells.
- Bioimpedance Spectroscopy.
- DNA variations, impaired insulin secretion and type 2 diabetes.
- Genetically programmed defects in beta-cell function.
- Proteomic analysis of the pancreatic islet ?-cell secretory granule: current understanding and future opportunities.
- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin).
- Present state of islet transplantation for type-1 diabetes patients.
- Predictive protein networks and identification of drugable targets in the beta-cell.
- Nanotoxicity.
- From silicon cell to silicon human.
- Probing Cellular Dynamics with Mesoscopic Simulations.
- What drives calcium oscillations in beta-cells? New tasks for cyclic analysis.
- Whole-body and cellular models of glucose-stimulated insulin secretion.
- Geometric and Electromagnetic Aspects of Fusion Pore Making.
- Index.

From the reviews:"This second volume is Springer's Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. ... I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research." (P. Meda, Diabetologia, Vol. 54, 2011)

From the reviews:"This second volume is Springer's Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. ... I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research." (P. Meda, Diabetologia, Vol. 54, 2011)