Advances in MALDI and Laser-Induced Soft Ionization Mass Spectrometry

(A) Novel methods in laser-induced desorption/ionization of biomolecules

Chapters on (1) rational design of MALDI matrices and samples (Jaskolla/Karas), (2) laser-induced formation of multiply charged ions (Cramer et al.), (3) ELDI and/or MALDESI (J. Loo and D. Muddiman), LSI (S. Trimpin) and (4) Liquid MALDI (Tholey/Cramer)

(B) Applications of liquid MALDI MS

Chapters on (1) Quantitation, (2) Coupling to liquid separation, (3) On-line reaction monitoring, (4) Glycan/Glycopeptide analysis, (5) Sensitivity improvements

Authors: K. Tanaka, R. Cramer, D. Armstrong, M. Gross, A. Tholey etc.

(C) MALDI body fluid profiling

Chapters on (large-scale) biomarker discovery studies in clinical proteomics including its pros and cons and the various application areas such as cancer proteomics.

Authors: E. Diamandis, J.F. Timms, C. Jimenez, J. Villanueva, H. Tammen, R. Banks, ...

(D) Advances in Clinical Microbiology

Chapters on MALDI in biotyping of clinically relevant microorganisms

Authors: S. Al-Dahouk, D. Raoult, D.M. Wolk, C. Fenselau, F. Szabados, P. Seng,

(E) MALDI biotyping beyond the clinic

Chapters on applying MALDI biotyping/speciation in the environmental sciences, food authentication, QC/QA etc.

Authors: C. Fenselau, R.A. Siciliano, I. Ortea, Q.X. Li, A. Chambery, etc.

(F) Advances in MALDI imaging

Chapters on the use of MALDI imaging in forensics (S. Francese), high resolution imaging (B. Spengler), latest methodologies (J. Bunch) as well as its application to lipids and the use of new instrumentation/methods such as LAESI (A. Vertes)