Acute Promyelocytic Leukemia
A Clinical Guide
(Sprache: Englisch)
This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL...
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This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.Inhaltsverzeichnis zu „Acute Promyelocytic Leukemia “
1 History of APLLaurent Degos 2 Molecular Targets of Treatment in APLRamy Rahmé, Cécile Esnault, Hugues de Thé3 The Leukemic Stem CellThalia Vlachou, Giulia De Conti, Anna Giulia Sanarico, Pier Giuseppe Pelicci
4 The Molecular Genetics of APLLourdes Mendez, Ming Chen, Pier Paolo Pandolfi
5 APL CoagulopathyAnna Falanga, Laura Russo, Pau Montesinos
6 Early Death in APLSören Lehmann
7 Prognostic Factors in APLJavier de la Serna, Pau Montesinos, Miguel A. Sanz
8 First-line therapy for APL: Chemotherapy-based approach Aaron D. Goldberg, Martin S. Tallman
9 First-line Therapy: ATRA-ATO/Reduced Chemotherapy ApproachHarry Iland
10 Cure of APL without ChemotherapyMary-Elizabeth M. Percival, Elihu H. Estey
11 Minimal Residual Disease in APLLaura Cicconi, Eva Barragàn
12 Treatment of refractory and relapsed APLEva Lengfelder
13 Hematopoietic Stem Cell Transplantation in APLJaime Sanz, Miguel A. Sanz
14 APL in ChildrenMatthew A. Kutny, Anna Maria Testi
15 Management of APL in the ElderlyRamy Rahmé, Lionel Adès, Pierre Fenaux
16 Special Situations in APLMassimo Breccia, Gloria Iacoboni, Miguel A. Sanz
17 APL in Developing Countries: A Chemotherapy-Based ApproachLuisa Corrêa de Araújo Koury, Raul Ribeiro, Eduardo M. Rego
18 APL in Developing Countries: ATO based ApproachVikram Mathews
19 Therapy-Related APLKristen Pettit, Richard A. Larson
20 Rare Acute Leukemia Variants involving Retinoic Acid Receptor GenesLaura Cicconi, Oussama Abla
21 Management of Treatment-Related Complications in APLOmbretta Annibali, Giuseppe Avvisati
Autoren-Porträt
Oussama Abla, MD The Hospital for Sick Children and University of Toronto
Division of Hematology/Oncology
Toronto, ON
Canada
Francesco Lo-Coco, MD
Professor of Hematology University of Tor Vergata
Bibliographische Angaben
- 2018, 1st ed. 2018, XII, 274 Seiten, 29 farbige Abbildungen, Masse: 18,2 x 26,4 cm, Gebunden, Englisch
- Herausgegeben: Oussama Abla, Francesco Lo Coco, Miguel A. Sanz
- Verlag: Springer, Berlin
- ISBN-10: 3319642561
- ISBN-13: 9783319642567
- Erscheinungsdatum: 11.05.2018
Sprache:
Englisch
Pressezitat
"This is a clinical guide to acute promyelocytic leukemia or APL, and it is the first book dedicated entirely to APL. Starting with an engaging historical account, the book provides a comprehensive overview of the clinical and basic aspects of APL, once regarded as the most fatal type of acute myeloid leukemia, but now considered the most curable. ... general practitioners and trainees also will find this book worth exploring ... ." (Ravi Salgia, Doody's Book Reviews, January 04, 2019)
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