Acrodermatitis Enteropathica

Part I: Overview of Disorder

1 History of Acrodermatitis Enteropathica

2 Epidemiology and Etiology

2.1 Epidemiology

2.2 Etiology

2.2.1 Molecular Etiology of AE

2.2.2 Hypothetical Etiology 1: the Alteration of Zinc Bioavailability

2.2.3 Hypothetical Etiology 2: a Defective Zinc Transporter

2.2.4 Alternative Forms of AE-like Zinc Deficiencies

3 Analysis of Disorder

3.1 Clinical Forms of AE

3.2 Nomenclature of Zinc Deficiencies

3.3 Acquired Non-hereditary Zinc Deficiency

3.3.1 Zinc Deficient Maternal Breast Milk

3.3.2 Zinc Deficient Caused by Metabolism Disorders

4 Clinical Symptoms

5 Diagnosis

5.1 Laboratory Diagnosis of Zinc Deficiency

5.2 Histopathology

5.3 Biological Diagnosis of AE

5.4 Clinical Diagnosis

5.5 Molecular Diagnosis

5.6 Differential Diagnosis

6 Disease Course and Treatment

6.1 Treatment

 

Part II: Review of Roles of Zinc in Metabolism

7 The Role of Zinc in Different Body Systems

 7.1 Biochemistry of Zinc Metabolism

7.2 Skin and Hair Physiology

7.3 Gastrointestinal System and Other Organs

7.4 Neurological Development, Growth, and Mental Status

7.5 Enzymes

7.6 Endocrine System

7.7 Metabolism of Nucleic Acids

7.8 Mitosis and Meiosis Cycles

7.9 Cell Membranes

7.10 Synthesis of Proteins and Collagen

7.11 Immune System

Part III: Case Descriptions of Acrodermatitis Enteropathica

8 History of AE in Adults

9 Iranian Hospital Cases in Literature

 9.1 Patient One

9.2 Patient Two

9.3 Patient Three

9.4 Patient Four

9.5 Zinc Deficiency Similarities to AE in Infants (Fifth Patient)

Part IV: Acrodermatitis Enteropathica Clinical Research

Pooya Khan Mohammad Beigi, MD, MSc, MPH is a Clinical Research Fellow at the University of British Columbia (Vancouver, BC, Canada). He is also the Founder/CEO of Misdiagnosis Association and Society (Seattle, WA, USA), and Founder/CEO of Father Medical Charity (Vancouver, BC, Canada).

Dr. Beigi established Misdiagnosis Association and Society (MARI), with the aim of collecting and preparing the most comprehensive database of errors in medicine and conducting related medical research studies, in collaboration with health organizations, universities, clinics, professors and physicians from all around the world.




Also, he founded Father Medical Charity with the goal of helping patients in need, especially those in underdeveloped countries. This Charity collaborates with many physicians and nurses employed in underdeveloped countries, who identify patients in need and refer them to this medical charity to receive the necessary medications or facilitate treatments for them.




Dr. Beigi has presented his research studies to several international conferences, including the 2nd BC eHealth and Innovative Technology, the Canadian Pharmacists 2015, and the 23rd World Congress of Dermatology, etc. He also has written several books for Springer including; Clinician's Guide to Acrodermatitis Enteropathica (2015), Clinician's Guide to Mycosis Fungoides (2016), Clinician's Guide to Pemphigus Vulgaris (2017), Psoriasis: A Clinician's Guide (in development), Clinician's Guide to Vitiligo and other Hypopigmentation Disorders (in development) and Clinician's Guide to Hyperpigmentation Disorders (in development).