What's Wrong With My Mouse? (PDF)

Dr. Jacqueline N. Crawley, author of the First and Second Editions
of What's Wrong with My Mouse? Behavioral Phenotyping of
Transgenic and Knockout Mice,continues to field calls and
e-mails from molecular geneticists who ask: how do I run
behavioral assays to find out what's wrong with my mouse?

Turn to What's Wrong with My Mouse? to discover the
wealth of mouse behavioral tasks and to get the guidance you need
to select the best methods and necessary controls. Chapters are
organized by behavioral domain, including measurements of general
health, motor functions, sensory abilities, learning and memory,
feeding and drinking, reproductive, social, emotional, and reward
behaviors in mutant mice. Throughout the chapters, new behavioral
tasks and new research discoveries have been added, bringing the
Second Edition up to date with the latest science. In addition, the
Second Edition includes two new chapters:

"Neurodevelopment and Neurodegeneration" discusses mouse
behavioral tasks relevant to neurodevelopmental diseases, such as
mental retardation and autism, and to neurodegenerative diseases,
such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic
lateral sclerosis.

"Putting It All Together" recommends strategies for optimizing a
battery of behavioral phenotyping tests to address your specific
hypotheses about gene functions.

The final chapter, "The Next Generation," examines new and
emerging technologies.

Throughout the book, the use of behavioral testing equipment is
illustrated with photographs, diagrams, and representative data.
Examples of behavioral tasks successfully applied to transgenic and
knockout mouse models are provided, as well as references to the
primary literature and step-by-step methods protocols. These
features, along with a comprehensive index, listings of database
and vendor websites, and an extensive list of references, make this
book a valuable and practical resource for students and
researchers.