The Chemistry and Biology of Nitroxyl (HNO) (ePub)
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The Chemistry and Biology of Nitroxyl (HNO) provides first-of-its-kind coverage of the intriguing biologically active molecule called nitroxyl, or azanone per IUPAC nomenclature, which has been traditionally elusive due to its intrinsically high reactivity.
This useful resource provides the scientific basis to understand the chemistry, biology, and technical aspects needed to deal with HNO. Building on two decades of nitric oxide and nitroxyl research, the editors and authors have created an indispensable guide for investigators across a wide variety of areas of chemistry (inorganic, organic, organometallic, biochemistry, physical, and analytical); biology (molecular, cellular, physiological, and enzymology); pharmacy; and medicine.
This book begins by exploring the unique molecule's structure and reactivity, including important reactions with small molecules, thiols, porphyrins, and key proteins, before discussing chemical and biological sources of nitroxyl. Advanced chapters discuss methods for both trapping and detecting nitroxyl by spectroscopy, electrochemistry, and fluorescent inorganic cellular probing.
Expanding on the compound's foundational chemistry, this book then explores its molecular physiology to offer insight into its biological implications, pharmacological effects, and practical issues.
- Presents the first book on HNO (nitroxyl or azanone), an increasingly important molecule in biochemistry and pharmaceutical research
- Provides a valuable coverage of HNO's chemical structure and significant reactions, including practical guidance on working with this highly reactive molecule
- Contains high quality content from recognized experts in both industry and academia
Professor and Chair of Chemistry and Biochemistry, Baylor University
Dr. Marcelo A. Martí earned his PhD in Biophysical Chemistry from the University of Buenos Aires (Argentina) in 2006 working with Prof. D.A. Estrín and F. Doctorovich. In this period, he pioneered the use of hybrid QM/MM based methods to study metalloprotein reactivity with Reactive Nitrogen and Oxygen Species (RNOS), while performing the first studies on HNO reactions with metallporphyrins. After his PhD, he worked on heme protein Raman spectroscopy in the field of protein electron transfer. In 2010, he accepted a professorship in the Department of Biological Chemistry at the University of Buenos Aires where he leads the protein structure biophysics and bioinformatics group. As a scientist in the triple frontier of chemistry, informatics, and biology, his research is focused on the comprehension of the
- 2016, 424 Seiten, Englisch
- Herausgegeben: Fabio Doctorovich, Patrick J. Farmer, Marcelo A. Marti
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0128011645
- ISBN-13: 9780128011645
- Erscheinungsdatum: 01.09.2016
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- Dateiformat: ePub
- Grösse: 13 MB
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