Coarse-Grained Modelling of DNA and DNA Self-Assembly / Springer Theses (PDF)
(Sprache: Englisch)
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in...
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This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.
Bibliographische Angaben
- Autor: Thomas E. Ouldridge
- 2012, 2012, 176 Seiten, Englisch
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3642305172
- ISBN-13: 9783642305177
- Erscheinungsdatum: 09.07.2012
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