Ryanodine Receptors / Developments in Cardiovascular Medicine Bd.254 (PDF)

Evolution of the ryanodine receptor gene family.- Topology and transmembrane organization of ryanodine receptors.- Three-dimensional reconstruction of ryanodine receptors.- RyR-DHPR relationships in skeletal and cardiac muscles.- The pore of the ryanodine receptor channel.- Inter-molecular domain-domain interaction: A key mechanism for calcium channel regulation of ryanodine receptors.- Regulation of sarcoplasmic reticulum calcium release by luminal calcium.- Cytosolic calcium regulation of single ryanodine receptor channels.- Elementary calcium release events: ryanodine receptor Ca2+ sparks.- Ca2+ release from the sarcoplasmic reticulum in intact cardiomyocytes.- Stability and instability of Ca2+ release from the SR.- Ryanodine receptors in smooth muscle.- Functions of RyR3 homologues.- Knockout mice lacking RyR and junctophilin subtypes.- Regulation of ryanodine receptor Ca22+ release by macromolecular complexes.- RyR1 modulation by calmodulin.- Ryanodine receptor function in inflammation.- Ryanoids, receptor affinity and RyR channel subconductance: Why the discordance?- Scorpion peptides as high-affinity probes of ryanodine receptor function.- Redox sensing by the ryanodine receptors.- Ryanodine receptor dysfunctin in the diabetic heart.- Molecular and clinical genetics of RyR1 disorders.- Pathophysiology of muscle disorders linked to mutations in the skeletal muscle ryanodine receptor.- The dantrolene binding site on RyR1: Implications for clinical therapy.- Ryanodine receptor dysfunction in heart failure and arrhythmias.- Stabilization of ryanodine receptor as a novel therapeutic strategy against heart failure.- Ryanodine receptor antibodies and myasthenia gravis.