Recent Advances in Transthyretin Evolution, Structure and Biological Functions (PDF)

Name: Recent Advances in Transthyretin Evolution, Structure and Biological Functions
Brand: Springer-Verlag GmbH
SKU: 29675493
Price: 271.50 CHF
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(Sprache: Englisch)

Autor: Vivian Cody

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Recent Advances in Transthyretin Evolution, Structure and Biological Functions, Vivian Cody

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There is a strong interest in transthyretin (TTR) in connection with protein evolution, medical and clinical research. Thus, this is an exciting time for experts in TTR research to come together to write a monograph covering both the basic and the...

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Transthyretin is a protein found in human blood and cerebrospinal fluid. It is directly involved in the transport of thyroid hormones, and indirectly in that of retinol. These hormones are essential for normal growth and development, particularly that of the brain. Spontaneous and inherited diseases affecting transthyretin result in amyloidosis. More than 80 point mutations in transthyretin lead to a variety of illnesses. Liver transplants are the most common treatment, although much research is also being carried out in drug therapies.

The evolution of transthyretin has been extensively investigated - from humans to bacteria, invertebrate animals and plants. The structure of the protein has not changed, but its function has changed significantly. This is a most exciting example for the study of the evolution of protein structure-function relationships.

This monograph will bring the reader up to date on the latest developments and discoveries.

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Autor: Vivian Cody
2009, 2009, 362 Seiten, Englisch
Herausgegeben: Samantha J. Richardson, Vivian Cody
Verlag: Springer-Verlag GmbH
ISBN-10: 3642006469
ISBN-13: 9783642006463
Erscheinungsdatum: 09.08.2009

Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.

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Grösse: 14 MB
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Englisch

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From the reviews:“Transthyretin (TTR) is a relatively abundant thyroid hormone carrier protein found in the blood of vertebrates. … The authors of the book Recent Advances in Transthyretin Evolution, Structure and Biological Functions have produced a comprehensive reference text that does much to reconcile the evolutionary biology, structure-function relationships and pathophysiology of this remarkable protein. … In summary, this … text will prove to be essential reading for both expert and non-expert researchers in the field of TTR biology.” (Rob Gasperini, Australian Biochemist, Vol. 41 (1), April, 2010)

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