Proteostasis and Proteolysis (PDF)

Niki Chondrogianni

Research areas: Ageing, longevity, age-related diseases, proteolysis, proteasome, redox regulation, cellular senescence, C. elegans

Dr. Chondrogianni graduated and obtained her PhD from the Department of Biology of the National and Kapodistrian University of Athens in Greece, while she was a visiting fellow at the Universities Paris 7 in France and Bristol in UK. She conducted her post-doctoral studies at the National Hellenic Research Foundation (NHRF) in Athens focusing on the role of proteasome activation on cellular and organismal lifespan extension. She was trained in the use of C. elegans at the Foundation of Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology in Greece. She established her lab at NHRF in 2009. She focuses on the genetic and environmental factors that govern ageing, longevity and age-related diseases with emphasis on proteasome regulation. She is seeking for natural or chemically-synthesized compounds that may act as proteasome activators and thus may serve as anti-ageing agents and/or as anti-aggregation compounds that can decelerate the progression of various proteinopathies with emphasis on Alzheimer's disease.

Elah Pick

Research areas: Cell biology, protein biochemistry, proteolysis, redox, the ubiquitin proteasome system

Prof. Elah Pick performed her graduate and postdoctoral training in cell Biochemistry, membrane traffic and protein degradation at the Technion - Israel Institute of Technology. She performed a second postdoctoral training at Yale university on a family of genes that regulate the molecular and biochemical mechanisms responsible for cellular responses to external stimuli and stresses. She established her own lab in Israel, at the department for Biology and Environment of the University of Haifa, located at Oranim. Her lab investigates the effect of metabolic and environmental stresses such as oxidation, on the regulation of