Physiologically Based Pharmacokinetic Modeling (PDF)

A definitive, single source of information on PBPK modeling

Physiologically-based pharmacokinetic (PBPK) modeling is becoming
increasingly important in human health risk assessments and in
supporting pharmacodynamic modeling for toxic responses. Organized
by classes of compounds and modeling purposes so users can quickly
access information, this is the first comprehensive reference of
its kind.

This book presents an overview of the underlying principles of PBPK
model development. Then it provides a compendium of PBPK modeling
information, including historical development, specific modeling
challenges, and current practices for:

* Halogenated Alkanes

* Halogenated Alkenes

* Alkene and Aromatic Compounds

* Reactive Vapors in the Nasal Cavity

* Alkanes, Oxyhydrocarbons, and Related Compounds

* Pesticides and Persistent Organic Pollutants

* Dioxin and Related Compounds

* Metals and Inorganic Compounds

* Drugs

* Antineoplastic Agents

* Perinatal Transfer

* Mixtures

* Dermal Exposure Models

In addition to pinpointing specific information, readers can
explore diverse modeling techniques and applications. An
authoritative reference for toxicologists, ecotoxicologists, risk
assessors, regulators, pharmacologists, pharmacists, and graduate
students in pharmacokinetics and toxicology, Physiologically-Based
Pharmacokinetic Modeling compiles information from leaders in the
field and discusses future directions for PBPK modeling.