Peptide Nucleic Acids, Morpholinos and Related Antisense Biomolecules / Medical Intelligence Unit (PDF)

The Many Faces of PNA.- Modulation of Nucleic Acid Information Processing by PNAs: Potential Use in Anti-Viral Therapeutics.- Targeted Gene Delivery: The Role of Peptide Nucleic Acid.- Imaging Gene Expression in the Brain with Peptide Nucleic Acid (PNA) Antisense Radiopharmaceuticals and Drug Targeting Technology.- Receptor-Specific Targeting with Complementary Peptide Nucleic Acids Conjugated to Peptide Analogs and Radionuclides.- Morpholinos and PNAs Compared.- Chemistry of Locked Nucleic Acids (LNA): Design, Synthesis and Bio-Physical Properties.- Recent Applications of RNA Interference (RNAi) in Mammalian Systems.- Peptide Nucleic Acids as Epigenetic Inhibitors of HIV-1.- Therapeutic Uses of Peptide Nucleic Acids (PNA) in Oncology.- PNAs as Novel Cancer Therapeutics.- Medicinal Chemistry of Plasmid DNA with Peptide Nucleic Acids:A New Strategy for Gene Therapy.- Locked Nucleic Acids (LNA) and Medical Applications.- Peptide Nucleic Acids as Agents to Modify Target Gene Expression and Function.- Peptide Nucleic Acids: Cellular Delivery and Recognition of DNA and RNA Targets.- The Use of PNAs and Their Derivatives in Mitochondrial Gene Therapy.- Gene Silencing through RNA Interference: Potential for Therapeutics and Functional Genomics.- Transcriptional Activation of Human CREB Gene Promoter Using Bis-PNA (Peptide Nucleic Acid).