Negative Affective States and Cognitive Impairments in Nicotine Dependence (ePub)
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Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions.
The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function.
- Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcement
- Examines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco use
- Includes both clinical and preclinical perspectives
- Includes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawal
- Emphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics
I am a Scottish Neuropsychopharmacologist in Sunny California, Dept. of Psychiatry, UCSD. My primary interest is investigating the neural mechanisms underlying cognitive dysfunction in order to develop targeted therapeutics. I specialize in cross-species testing and as such have developed/aided in the development of many such tests including the 5-choice continuous performance test, now in use across the globe, in patients, rats, and mice, with fMRI and EEG recording also available. With regards to clinical populations, I have investigated diseases such as schizophrenia, bipolar disorder, HIV, Tourette’s syndrome, as well as methamphetamine, nicotine, and cannabis abuse. Using this cross-species behavioral testing approach, any work we conduct we hope will have relevance to clinical populations and vice-versa. With this dual approach combined with networking with great collaborators, I hope that more promising therapeutics will not be far away.
Andre Der-Avakian, Ph.D., is an Assistant Research
- 2016, 362 Seiten, Englisch
- Herausgegeben: F. Scott Hall, Jared W. Young, Andre Der-Avakian
- Verlag: Elsevier Science & Techn.
- ISBN-10: 0128026693
- ISBN-13: 9780128026694
- Erscheinungsdatum: 17.08.2016
Abhängig von Bildschirmgrösse und eingestellter Schriftgrösse kann die Seitenzahl auf Ihrem Lesegerät variieren.
- Dateiformat: ePub
- Grösse: 13 MB
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